#------------------------------------------------------------------------------ #$Date: 2020-07-06 06:43:16 +0300 (Mon, 06 Jul 2020) $ #$Revision: 253971 $ #$URL: file:///home/coder/svn-repositories/cod/cif/7/15/75/7157515.cif $ #------------------------------------------------------------------------------ # # This file is available in the Crystallography Open Database (COD), # http://www.crystallography.net/ # # All data on this site have been placed in the public domain by the # contributors. # data_7157515 loop_ _publ_author_name 'Luo, Si-Qin' 'Liu, Wei' 'Ruan, Ban-Feng' 'Fan, Shi-Lu' 'Zhu, Hui-Xia' 'Tao, Wei' 'Xiao, Hua' _publ_section_title ; P(NMe2)3 mediated cyclopropanation of \a-methylene-\b-lactams for rapid syntheses of spirocyclopropyl \b-lactams. ; _journal_issue 24 _journal_name_full 'Organic & biomolecular chemistry' _journal_page_first 4599 _journal_page_last 4603 _journal_paper_doi 10.1039/d0ob00826e _journal_volume 18 _journal_year 2020 _chemical_formula_moiety 'C28 H25 N O6' _chemical_formula_sum 'C28 H25 N O6' _chemical_formula_weight 471.49 _space_group_crystal_system triclinic _space_group_IT_number 2 _space_group_name_Hall '-P 1' _space_group_name_H-M_alt 'P -1' _atom_sites_solution_hydrogens geom _atom_sites_solution_primary direct _audit_creation_date 2019-10-22 _audit_creation_method ; Olex2 1.2 (compiled 2018.05.29 svn.r3508 for OlexSys, GUI svn.r5506) ; _audit_update_record ; 2019-11-20 deposited with the CCDC. 2020-05-20 downloaded from the CCDC. ; _cell_angle_alpha 103.598(4) _cell_angle_beta 99.511(4) _cell_angle_gamma 95.686(4) _cell_formula_units_Z 4 _cell_length_a 10.6091(5) _cell_length_b 11.9396(5) _cell_length_c 20.1405(8) _cell_measurement_reflns_used 5846 _cell_measurement_temperature 292.01(10) _cell_measurement_theta_max 69.7230 _cell_measurement_theta_min 6.1370 _cell_volume 2420.12(19) _computing_cell_refinement ; CrysAlisPro, Agilent Technologies, Version 1.171.36.28 (release 01-02-2013 CrysAlis171 .NET) (compiled Feb 1 2013,16:14:44) ; _computing_data_collection ; CrysAlisPro, Agilent Technologies, Version 1.171.36.28 (release 01-02-2013 CrysAlis171 .NET) (compiled Feb 1 2013,16:14:44) ; _computing_data_reduction ; CrysAlisPro, Agilent Technologies, Version 1.171.36.28 (release 01-02-2013 CrysAlis171 .NET) (compiled Feb 1 2013,16:14:44) ; _computing_molecular_graphics 'Olex2 (Dolomanov et al., 2009)' _computing_publication_material 'Olex2 (Dolomanov et al., 2009)' _computing_structure_refinement 'ShelXL (Sheldrick, 2015)' _computing_structure_solution 'ShelXS (Sheldrick, 2008)' _diffrn_ambient_temperature 292.01(10) _diffrn_detector_area_resol_mean 16.0733 _diffrn_measured_fraction_theta_full 0.996 _diffrn_measured_fraction_theta_max 0.996 _diffrn_measurement_details ; #__ type_ start__ end____ width___ exp.time_ 1 omega -63.00 -23.00 1.0000 3.0000 omega____ theta____ kappa____ phi______ frames - -8.5000 -57.0000 60.0000 40 #__ type_ start__ end____ width___ exp.time_ 2 omega -84.00 -38.00 1.0000 3.0000 omega____ theta____ kappa____ phi______ frames - -8.5000 178.0000 120.0000 46 #__ type_ start__ end____ width___ exp.time_ 3 omega 29.00 60.00 1.0000 3.0000 omega____ theta____ kappa____ phi______ frames - -8.5000 57.0000 30.0000 31 #__ type_ start__ end____ width___ exp.time_ 4 omega -15.00 11.00 1.0000 3.0000 omega____ theta____ kappa____ phi______ frames - -8.5000 -57.0000 60.0000 26 #__ type_ start__ end____ width___ exp.time_ 5 omega -27.00 4.00 1.0000 3.0000 omega____ theta____ kappa____ phi______ frames - -8.5000 57.0000 30.0000 31 #__ type_ start__ end____ width___ exp.time_ 6 omega -85.00 -34.00 1.0000 3.0000 omega____ theta____ kappa____ phi______ frames - -8.5000 178.0000 -150.0000 51 #__ type_ start__ end____ width___ exp.time_ 7 omega 41.00 110.00 1.0000 3.0000 omega____ theta____ kappa____ phi______ frames - 54.0000 -125.0000 -180.0000 69 #__ type_ start__ end____ width___ exp.time_ 8 omega -9.00 24.00 1.0000 3.0000 omega____ theta____ kappa____ phi______ frames - 54.0000 -57.0000 -30.0000 33 #__ type_ start__ end____ width___ exp.time_ 9 omega 32.00 123.00 1.0000 3.0000 omega____ theta____ kappa____ phi______ frames - 54.0000 57.0000 120.0000 91 #__ type_ start__ end____ width___ exp.time_ 10 omega 29.00 76.00 1.0000 3.0000 omega____ theta____ kappa____ phi______ frames - 54.0000 -57.0000 -30.0000 47 #__ type_ start__ end____ width___ exp.time_ 11 omega 32.00 111.00 1.0000 3.0000 omega____ theta____ kappa____ phi______ frames - 54.0000 57.0000 -150.0000 79 #__ type_ start__ end____ width___ exp.time_ 12 omega 20.00 45.00 1.0000 3.0000 omega____ theta____ kappa____ phi______ frames - 54.0000 81.0000 -60.9645 25 #__ type_ start__ end____ width___ exp.time_ 13 omega 74.00 110.00 1.0000 6.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 -111.0000 -90.0000 36 #__ type_ start__ end____ width___ exp.time_ 14 omega 82.00 162.00 1.0000 6.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 77.0000 -60.0000 80 #__ type_ start__ end____ width___ exp.time_ 15 omega 50.00 88.00 1.0000 6.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 -25.0000 -150.0000 38 #__ type_ start__ end____ width___ exp.time_ 16 omega 89.00 115.00 1.0000 6.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 -111.0000 60.0000 26 #__ type_ start__ end____ width___ exp.time_ 17 omega 146.00 173.00 1.0000 6.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 38.0000 30.0000 27 #__ type_ start__ end____ width___ exp.time_ 18 omega 35.00 87.00 1.0000 6.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 -38.0000 0.0000 52 #__ type_ start__ end____ width___ exp.time_ 19 omega 97.00 172.00 1.0000 6.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 0.0000 -90.0000 75 #__ type_ start__ end____ width___ exp.time_ 20 omega 35.00 79.00 1.0000 6.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 0.0000 -90.0000 44 #__ type_ start__ end____ width___ exp.time_ 21 omega 66.00 91.00 1.0000 6.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 -38.0000 -120.0000 25 #__ type_ start__ end____ width___ exp.time_ 22 omega 82.00 135.00 1.0000 6.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 38.0000 30.0000 53 #__ type_ start__ end____ width___ exp.time_ 23 omega 38.00 107.00 1.0000 6.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 -111.0000 -180.0000 69 #__ type_ start__ end____ width___ exp.time_ 24 omega 40.00 94.00 1.0000 6.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 -25.0000 120.0000 54 #__ type_ start__ end____ width___ exp.time_ 25 omega 54.00 80.00 1.0000 6.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 -38.0000 30.0000 26 #__ type_ start__ end____ width___ exp.time_ 26 omega 57.00 137.00 1.0000 6.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 178.0000 -150.0000 80 #__ type_ start__ end____ width___ exp.time_ 27 omega 88.00 113.00 1.0000 6.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 63.0000 -30.0000 25 #__ type_ start__ end____ width___ exp.time_ 28 omega 77.00 132.00 1.0000 6.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 -63.0000 -90.0000 55 #__ type_ start__ end____ width___ exp.time_ 29 omega 35.00 147.00 1.0000 6.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 -91.0000 -60.0000 112 #__ type_ start__ end____ width___ exp.time_ 30 omega 46.00 92.00 1.0000 6.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 -38.0000 -180.0000 46 #__ type_ start__ end____ width___ exp.time_ 31 omega 45.00 71.00 1.0000 6.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 -25.0000 60.0000 26 #__ type_ start__ end____ width___ exp.time_ 32 omega 120.00 146.00 1.0000 6.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 111.0000 120.0000 26 #__ type_ start__ end____ width___ exp.time_ 33 omega 41.00 131.00 1.0000 6.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 -63.0000 150.0000 90 #__ type_ start__ end____ width___ exp.time_ 34 omega -79.00 23.00 1.0000 3.0000 omega____ theta____ kappa____ phi______ frames - -8.5000 -77.0000 -30.0000 102 #__ type_ start__ end____ width___ exp.time_ 35 omega -30.00 61.00 1.0000 3.0000 omega____ theta____ kappa____ phi______ frames - -8.5000 57.0000 90.0000 91 #__ type_ start__ end____ width___ exp.time_ 36 omega 27.00 127.00 1.0000 3.0000 omega____ theta____ kappa____ phi______ frames - 54.0000 38.0000 -150.0000 100 #__ type_ start__ end____ width___ exp.time_ 37 omega 32.00 123.00 1.0000 3.0000 omega____ theta____ kappa____ phi______ frames - 54.0000 57.0000 -30.0000 91 #__ type_ start__ end____ width___ exp.time_ 38 omega 20.00 46.00 1.0000 3.0000 omega____ theta____ kappa____ phi______ frames - 54.0000 81.0000 -99.4191 26 #__ type_ start__ end____ width___ exp.time_ 39 omega 22.00 49.00 1.0000 3.0000 omega____ theta____ kappa____ phi______ frames - 54.0000 78.0000 80.8289 27 #__ type_ start__ end____ width___ exp.time_ 40 omega -15.00 76.00 1.0000 3.0000 omega____ theta____ kappa____ phi______ frames - 54.0000 -57.0000 30.0000 91 #__ type_ start__ end____ width___ exp.time_ 41 omega 32.00 123.00 1.0000 3.0000 omega____ theta____ kappa____ phi______ frames - 54.0000 57.0000 30.0000 91 #__ type_ start__ end____ width___ exp.time_ 42 omega -15.00 76.00 1.0000 3.0000 omega____ theta____ kappa____ phi______ frames - 54.0000 -57.0000 -180.0000 91 #__ type_ start__ end____ width___ exp.time_ 43 omega 76.00 178.00 1.0000 6.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 77.0000 -90.0000 102 #__ type_ start__ end____ width___ exp.time_ 44 omega 76.00 178.00 1.0000 6.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 77.0000 30.0000 102 #__ type_ start__ end____ width___ exp.time_ 45 omega 81.00 178.00 1.0000 6.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 38.0000 -150.0000 97 #__ type_ start__ end____ width___ exp.time_ 46 omega 68.00 178.00 1.0000 6.0000 omega____ theta____ kappa____ phi______ frames - 108.0000 25.0000 120.0000 110 ; _diffrn_measurement_device_type 'SuperNova, Dual, Cu at zero, Eos' _diffrn_measurement_method '\w scans' _diffrn_orient_matrix_UB_11 0.0488413000 _diffrn_orient_matrix_UB_12 0.1076485000 _diffrn_orient_matrix_UB_13 0.0618287000 _diffrn_orient_matrix_UB_21 0.1391527000 _diffrn_orient_matrix_UB_22 -0.0058499000 _diffrn_orient_matrix_UB_23 -0.0120126000 _diffrn_orient_matrix_UB_31 -0.0196906000 _diffrn_orient_matrix_UB_32 0.0798305000 _diffrn_orient_matrix_UB_33 -0.0497056000 _diffrn_radiation_monochromator mirror _diffrn_radiation_type CuK\a _diffrn_radiation_wavelength 1.54184 _diffrn_reflns_av_R_equivalents 0.0435 _diffrn_reflns_av_unetI/netI 0.0486 _diffrn_reflns_Laue_measured_fraction_full 0.996 _diffrn_reflns_Laue_measured_fraction_max 0.996 _diffrn_reflns_limit_h_max 12 _diffrn_reflns_limit_h_min -12 _diffrn_reflns_limit_k_max 14 _diffrn_reflns_limit_k_min -13 _diffrn_reflns_limit_l_max 22 _diffrn_reflns_limit_l_min -23 _diffrn_reflns_number 26969 _diffrn_reflns_point_group_measured_fraction_full 0.996 _diffrn_reflns_point_group_measured_fraction_max 0.996 _diffrn_reflns_theta_full 66.598 _diffrn_reflns_theta_max 66.598 _diffrn_reflns_theta_min 3.849 _diffrn_source 'SuperNova (Cu) X-ray Source' _exptl_absorpt_coefficient_mu 0.749 _exptl_absorpt_correction_T_max 1.00000 _exptl_absorpt_correction_T_min 0.45240 _exptl_absorpt_correction_type multi-scan _exptl_absorpt_process_details ; CrysAlisPro, Agilent Technologies, Version 1.171.36.28 (release 01-02-2013 CrysAlis171 .NET) (compiled Feb 1 2013,16:14:44) Empirical absorption correction using spherical harmonics, implemented in SCALE3 ABSPACK scaling algorithm. ; _exptl_crystal_colour 'clear light colourless' _exptl_crystal_colour_lustre clear _exptl_crystal_colour_modifier light _exptl_crystal_colour_primary colourless _exptl_crystal_density_diffrn 1.294 _exptl_crystal_description block _exptl_crystal_F_000 992 _exptl_crystal_size_max 0.13 _exptl_crystal_size_mid 0.09 _exptl_crystal_size_min 0.07 _refine_diff_density_max 0.504 _refine_diff_density_min -0.278 _refine_diff_density_rms 0.043 _refine_ls_extinction_method none _refine_ls_goodness_of_fit_ref 1.025 _refine_ls_hydrogen_treatment constr _refine_ls_matrix_type full _refine_ls_number_parameters 635 _refine_ls_number_reflns 8518 _refine_ls_number_restraints 0 _refine_ls_restrained_S_all 1.025 _refine_ls_R_factor_all 0.0751 _refine_ls_R_factor_gt 0.0526 _refine_ls_shift/su_max 0.000 _refine_ls_shift/su_mean 0.000 _refine_ls_structure_factor_coef Fsqd _refine_ls_weighting_details 'w=1/[\s^2^(Fo^2^)+(0.0630P)^2^+0.4582P] where P=(Fo^2^+2Fc^2^)/3' _refine_ls_weighting_scheme calc _refine_ls_wR_factor_gt 0.1282 _refine_ls_wR_factor_ref 0.1479 _reflns_Friedel_coverage 0.000 _reflns_number_gt 6086 _reflns_number_total 8518 _reflns_threshold_expression 'I > 2\s(I)' _cod_data_source_file d0ob00826e2.cif _cod_data_source_block xc-1 _cod_depositor_comments 'Adding full bibliography for 7157515--7157516.cif.' _cod_original_cell_volume 2420.12(18) _cod_database_code 7157515 _shelx_shelxl_version_number 2018/3 _shelx_space_group_comment ; The symmetry employed for this shelxl refinement is uniquely defined by the following loop, which should always be used as a source of symmetry information in preference to the above space-group names. They are only intended as comments. ; _reflns_odcompleteness_completeness 99.63 _reflns_odcompleteness_iscentric 1 _reflns_odcompleteness_theta 66.97 _olex2_refinement_description ; 1. Fixed Uiso At 1.2 times of: All C(H) groups, All C(H,H) groups At 1.5 times of: All C(H,H,H) groups 2.a Secondary CH2 refined with riding coordinates: C9(H9A,H9B), C10(H10A,H10B), C37(H37A,H37B), C38(H38A,H38B) 2.b Aromatic/amide H refined with riding coordinates: C1(H1), C2(H2), C3(H3), C4(H4), C5(H5), C14(H14), C15(H15), C16(H16), C17(H17), C18(H18), C22(H22), C23(H23), C24(H24), C25(H25), C26(H26), C29(H29), C30(H30), C31(H31), C32(H32), C33(H33), C42(H42), C43(H43), C44(H44), C45(H45), C46(H46), C52(H52), C53(H53), C54(H54), C55(H55), C56(H56) 2.c Idealised Me refined as rotating group: C20(H20A,H20B,H20C), C28(H28A,H28B,H28C), C48(H48A,H48B,H48C), C50(H50A,H50B, H50C) ; _shelx_res_file ; TITL XC-1 in P-1 #2 xc-1.res created by SHELXL-2018/3 at 12:07:50 on 22-Oct-2019 REM reset to P-1 #2 CELL 1.54184 10.609054 11.939587 20.140541 103.5978 99.5107 95.6863 ZERR 4 0.000484 0.000493 0.000816 0.0036 0.0037 0.0036 LATT 1 SFAC C H N O UNIT 112 100 4 24 L.S. 10 PLAN 20 BOND $H HTAB CONF fmap 2 acta SHEL 999 0.84 REM REM REM WGHT 0.063000 0.458200 FVAR 6.20879 O1 4 0.341523 0.497002 0.317500 11.00000 0.05430 0.03415 = 0.06039 0.01193 0.01426 0.00668 O2 4 0.600216 0.366115 0.244659 11.00000 0.03893 0.04719 = 0.04856 0.01625 0.00950 0.00027 O3 4 0.478477 0.102534 0.190177 11.00000 0.07008 0.04827 = 0.06550 -0.00493 0.01060 0.00670 O4 4 0.649408 0.135841 0.275996 11.00000 0.06649 0.05782 = 0.07508 0.00943 0.00713 0.02734 O5 4 0.696432 0.243866 0.139115 11.00000 0.07158 0.07817 = 0.09783 0.01519 0.03662 0.02875 O6 4 0.518251 0.242610 0.062609 11.00000 0.09853 0.06052 = 0.05447 0.00415 0.02342 0.00951 N1 3 0.231068 0.308007 0.298386 11.00000 0.04214 0.03629 = 0.05238 0.00998 0.01620 -0.00063 C1 1 0.069716 0.199798 0.338431 11.00000 0.05779 0.05888 = 0.06566 0.02310 0.02288 0.00105 AFIX 43 H1 2 0.099002 0.131094 0.318746 11.00000 -1.20000 AFIX 0 C2 1 -0.033734 0.197302 0.372431 11.00000 0.06673 0.08983 = 0.08415 0.04317 0.03179 0.00011 AFIX 43 H2 2 -0.072919 0.126228 0.375864 11.00000 -1.20000 AFIX 0 C3 1 -0.079051 0.296799 0.400872 11.00000 0.05792 0.11326 = 0.07433 0.04197 0.03275 0.01721 AFIX 43 H3 2 -0.150057 0.293635 0.422312 11.00000 -1.20000 AFIX 0 C4 1 -0.018851 0.401285 0.397494 11.00000 0.07351 0.09007 = 0.09356 0.02390 0.04398 0.03069 AFIX 43 H4 2 -0.047924 0.469652 0.417948 11.00000 -1.20000 AFIX 0 C5 1 0.085306 0.407060 0.363929 11.00000 0.06046 0.05964 = 0.08097 0.01528 0.03087 0.01072 AFIX 43 H5 2 0.125257 0.478576 0.361579 11.00000 -1.20000 AFIX 0 C6 1 0.128482 0.305507 0.334231 11.00000 0.04044 0.05497 = 0.04196 0.01604 0.00967 0.00190 C7 1 0.322391 0.392338 0.293520 11.00000 0.03920 0.03451 = 0.04105 0.01358 0.00395 0.00385 C8 1 0.383867 0.304431 0.244861 11.00000 0.03558 0.03713 = 0.03714 0.01075 0.00439 -0.00132 C9 1 0.275549 0.213052 0.251161 11.00000 0.03982 0.03597 = 0.04511 0.00589 0.00956 -0.00111 AFIX 23 H9A 2 0.214346 0.178093 0.207989 11.00000 -1.20000 H9B 2 0.306566 0.154137 0.273037 11.00000 -1.20000 AFIX 0 C10 1 0.390051 0.329815 0.174491 11.00000 0.04631 0.05491 = 0.04166 0.01471 0.00675 -0.00411 AFIX 23 H10A 2 0.342596 0.393237 0.168380 11.00000 -1.20000 H10B 2 0.354227 0.261481 0.136675 11.00000 -1.20000 AFIX 0 C11 1 0.535579 0.363748 0.176656 11.00000 0.04745 0.04443 = 0.04241 0.01016 0.01329 0.00042 C12 1 0.524193 0.291050 0.273783 11.00000 0.03876 0.03607 = 0.04431 0.01188 0.00925 0.00245 C13 1 0.562012 0.327524 0.352389 11.00000 0.03863 0.03961 = 0.04434 0.01087 0.00402 0.00833 C14 1 0.517788 0.256774 0.391051 11.00000 0.05957 0.05514 = 0.04891 0.01531 0.00379 -0.00633 AFIX 43 H14 2 0.468968 0.184719 0.368501 11.00000 -1.20000 AFIX 0 C15 1 0.545121 0.291583 0.463359 11.00000 0.06717 0.07594 = 0.04843 0.02427 0.00874 0.00638 AFIX 43 H15 2 0.515482 0.242364 0.488798 11.00000 -1.20000 AFIX 0 C16 1 0.615083 0.397395 0.497164 11.00000 0.07076 0.07124 = 0.04208 0.00945 0.00518 0.02740 AFIX 43 H16 2 0.631953 0.421288 0.545558 11.00000 -1.20000 AFIX 0 C17 1 0.660149 0.467949 0.459487 11.00000 0.08014 0.04703 = 0.05462 0.00136 -0.00832 0.00573 AFIX 43 H17 2 0.709753 0.539422 0.482570 11.00000 -1.20000 AFIX 0 C18 1 0.633180 0.434836 0.386946 11.00000 0.06620 0.04102 = 0.05193 0.01272 0.00280 0.00469 AFIX 43 H18 2 0.662902 0.484673 0.361885 11.00000 -1.20000 AFIX 0 C19 1 0.546275 0.164199 0.241621 11.00000 0.04664 0.03917 = 0.05264 0.01154 0.01597 0.00503 C20 1 0.680398 0.021248 0.246503 11.00000 0.09816 0.06730 = 0.11182 0.01204 0.02278 0.04753 AFIX 137 H20A 2 0.696775 0.016982 0.200563 11.00000 -1.50000 H20B 2 0.609100 -0.036753 0.244018 11.00000 -1.50000 H20C 2 0.755825 0.007680 0.275409 11.00000 -1.50000 AFIX 0 C21 1 0.571221 0.481550 0.162346 11.00000 0.05096 0.04245 = 0.04642 0.00717 0.02052 0.00337 C22 1 0.678852 0.557173 0.201926 11.00000 0.04918 0.05511 = 0.07844 0.01721 0.01224 0.00047 AFIX 43 H22 2 0.727884 0.538640 0.239541 11.00000 -1.20000 AFIX 0 C23 1 0.713441 0.661011 0.185248 11.00000 0.06576 0.05532 = 0.11239 0.02232 0.01825 -0.01193 AFIX 43 H23 2 0.785308 0.712099 0.212334 11.00000 -1.20000 AFIX 0 C24 1 0.643474 0.689378 0.129593 11.00000 0.09606 0.05072 = 0.09457 0.02892 0.04379 0.00438 AFIX 43 H24 2 0.668524 0.758564 0.118548 11.00000 -1.20000 AFIX 0 C25 1 0.536875 0.615536 0.090493 11.00000 0.10449 0.05802 = 0.05680 0.02615 0.02469 0.00961 AFIX 43 H25 2 0.488499 0.634722 0.052922 11.00000 -1.20000 AFIX 0 C26 1 0.500396 0.511807 0.106631 11.00000 0.07757 0.05223 = 0.04872 0.01279 0.01057 -0.00441 AFIX 43 H26 2 0.427488 0.461957 0.079714 11.00000 -1.20000 AFIX 0 C27 1 0.595434 0.274430 0.125279 11.00000 0.06655 0.04363 = 0.05465 0.01416 0.01847 -0.00084 C28 1 0.576803 0.165159 0.011544 11.00000 0.15455 0.07428 = 0.07874 -0.00339 0.05584 0.02395 AFIX 137 H28A 2 0.523104 0.149447 -0.033848 11.00000 -1.50000 H28B 2 0.584540 0.093369 0.024504 11.00000 -1.50000 H28C 2 0.660864 0.202260 0.010748 11.00000 -1.50000 AFIX 0 O7 4 0.323846 0.990673 0.318106 11.00000 0.05996 0.03069 = 0.05986 0.00692 0.00316 0.00438 O8 4 0.058463 0.802530 0.191492 11.00000 0.03990 0.04216 = 0.03503 0.01362 0.00673 0.00709 O9 4 0.165623 0.568254 0.153517 11.00000 0.06666 0.04501 = 0.05769 -0.00557 0.02281 0.00132 O10 4 0.011944 0.560016 0.216057 11.00000 0.05969 0.03480 = 0.07001 0.00153 0.02324 -0.00862 O11 4 0.117063 0.698446 0.021500 11.00000 0.07349 0.05359 = 0.04239 0.00260 0.01678 0.00741 O12 4 -0.061272 0.689603 0.066831 11.00000 0.05227 0.05881 = 0.04967 -0.00686 0.00261 -0.00470 N2 3 0.436853 0.829913 0.312102 11.00000 0.04545 0.03610 = 0.04153 0.00552 -0.00139 0.00559 C29 1 0.606097 0.758419 0.377984 11.00000 0.05320 0.05491 = 0.06821 0.01943 -0.00535 0.00214 AFIX 43 H29 2 0.586411 0.687213 0.344782 11.00000 -1.20000 AFIX 0 C30 1 0.704199 0.774071 0.435396 11.00000 0.05749 0.08143 = 0.09037 0.03839 -0.01263 0.00442 AFIX 43 H30 2 0.750914 0.713628 0.440367 11.00000 -1.20000 AFIX 0 C31 1 0.732557 0.877921 0.484713 11.00000 0.05332 0.11368 = 0.05945 0.02675 -0.00934 -0.00589 AFIX 43 H31 2 0.797730 0.888107 0.523563 11.00000 -1.20000 AFIX 0 C32 1 0.665165 0.966095 0.476721 11.00000 0.07071 0.09357 = 0.06532 -0.01469 -0.01568 0.00120 AFIX 43 H32 2 0.684958 1.036962 0.510228 11.00000 -1.20000 AFIX 0 C33 1 0.566990 0.952275 0.419266 11.00000 0.06820 0.06373 = 0.06992 -0.00630 -0.01359 0.01155 AFIX 43 H33 2 0.521284 1.013283 0.414175 11.00000 -1.20000 AFIX 0 C34 1 0.538292 0.847191 0.370024 11.00000 0.03931 0.04706 = 0.04500 0.01444 0.00305 0.00102 C35 1 0.342803 0.892626 0.293491 11.00000 0.04111 0.03150 = 0.04240 0.01109 0.00546 0.00156 C36 1 0.276808 0.792537 0.230610 11.00000 0.03860 0.02816 = 0.03858 0.00883 0.00709 0.00390 C37 1 0.387526 0.726094 0.253864 11.00000 0.04056 0.03376 = 0.04297 0.00875 0.00581 0.00454 AFIX 23 H37A 2 0.358961 0.657239 0.268139 11.00000 -1.20000 H37B 2 0.444765 0.709242 0.221030 11.00000 -1.20000 AFIX 0 C38 1 0.264328 0.819394 0.159328 11.00000 0.04415 0.04451 = 0.04213 0.01539 0.01003 0.00388 AFIX 23 H38A 2 0.294269 0.759452 0.126559 11.00000 -1.20000 H38B 2 0.314288 0.893932 0.163015 11.00000 -1.20000 AFIX 0 C39 1 0.119222 0.822199 0.135865 11.00000 0.04554 0.03616 = 0.03137 0.01097 0.00714 0.00496 C40 1 0.137206 0.745228 0.233720 11.00000 0.03766 0.03140 = 0.03585 0.00863 0.00479 0.00368 C41 1 0.103919 0.773044 0.305744 11.00000 0.04098 0.03166 = 0.03466 0.00814 0.00708 0.00130 C42 1 0.021094 0.852513 0.323373 11.00000 0.06265 0.04794 = 0.04405 0.01657 0.01607 0.01751 AFIX 43 H42 2 -0.014173 0.890899 0.291148 11.00000 -1.20000 AFIX 0 C43 1 -0.009491 0.875067 0.389220 11.00000 0.08050 0.06499 = 0.05755 0.01755 0.03365 0.03139 AFIX 43 H43 2 -0.067042 0.927087 0.400512 11.00000 -1.20000 AFIX 0 C44 1 0.044541 0.821201 0.437683 11.00000 0.07994 0.07848 = 0.03954 0.01589 0.02253 0.02087 AFIX 43 H44 2 0.024744 0.837394 0.481940 11.00000 -1.20000 AFIX 0 C45 1 0.127733 0.743506 0.420604 11.00000 0.07223 0.07895 = 0.04281 0.02712 0.01585 0.02441 AFIX 43 H45 2 0.164181 0.706431 0.453263 11.00000 -1.20000 AFIX 0 C46 1 0.157881 0.719851 0.354887 11.00000 0.05712 0.05361 = 0.04613 0.01935 0.01561 0.01766 AFIX 43 H46 2 0.215196 0.667468 0.343858 11.00000 -1.20000 AFIX 0 C47 1 0.109091 0.614043 0.196749 11.00000 0.04368 0.03344 = 0.04007 0.00933 0.00514 0.00089 C48 1 -0.026493 0.437034 0.180669 11.00000 0.08153 0.03796 = 0.09256 -0.00250 0.01990 -0.01595 AFIX 137 H48A 2 -0.066766 0.429231 0.133168 11.00000 -1.50000 H48B 2 -0.086419 0.402885 0.203736 11.00000 -1.50000 H48C 2 0.048387 0.397967 0.181788 11.00000 -1.50000 AFIX 0 C49 1 0.061244 0.727822 0.068150 11.00000 0.05255 0.03130 = 0.03938 0.00889 0.00433 0.00581 C50 1 -0.132214 0.606694 0.003899 11.00000 0.07000 0.07011 = 0.06505 -0.01038 -0.00884 -0.01091 AFIX 137 H50A 2 -0.124841 0.637216 -0.035560 11.00000 -1.50000 H50B 2 -0.221529 0.593283 0.007003 11.00000 -1.50000 H50C 2 -0.097270 0.534659 -0.001434 11.00000 -1.50000 AFIX 0 C51 1 0.084861 0.936301 0.121120 11.00000 0.05231 0.03377 = 0.03315 0.00551 -0.00078 0.00357 C52 1 -0.016767 0.985381 0.144277 11.00000 0.06166 0.05172 = 0.05844 0.01856 0.00915 0.01712 AFIX 43 H52 2 -0.063659 0.950328 0.170981 11.00000 -1.20000 AFIX 0 C53 1 -0.050171 1.086654 0.128252 11.00000 0.07582 0.05668 = 0.07534 0.01978 0.00725 0.02979 AFIX 43 H53 2 -0.118141 1.119745 0.145059 11.00000 -1.20000 AFIX 0 C54 1 0.016088 1.138353 0.087883 11.00000 0.10148 0.03908 = 0.05147 0.01425 -0.01074 0.01591 AFIX 43 H54 2 -0.007228 1.205720 0.076711 11.00000 -1.20000 AFIX 0 C55 1 0.117212 1.089668 0.064115 11.00000 0.09528 0.04098 = 0.03926 0.01100 -0.00223 -0.00230 AFIX 43 H55 2 0.162519 1.124381 0.036653 11.00000 -1.20000 AFIX 0 C56 1 0.152637 0.989444 0.080525 11.00000 0.06949 0.03946 = 0.03908 0.01016 0.00782 0.00459 AFIX 43 H56 2 0.221823 0.957596 0.064395 11.00000 -1.20000 AFIX 0 HKLF 4 REM XC-1 in P-1 #2 REM wR2 = 0.1479, GooF = S = 1.025, Restrained GooF = 1.025 for all data REM R1 = 0.0526 for 6086 Fo > 4sig(Fo) and 0.0751 for all 8518 data REM 635 parameters refined using 0 restraints END WGHT 0.0630 0.4582 REM Instructions for potential hydrogen bonds HTAB C5 O1 EQIV $1 x, y-1, z HTAB C9 O7_$1 HTAB C33 O7 HTAB C37 O1 REM Highest difference peak 0.504, deepest hole -0.278, 1-sigma level 0.043 Q1 1 0.4227 0.2427 0.0518 11.00000 0.05 0.50 Q2 1 0.6781 0.1616 0.0553 11.00000 0.05 0.34 Q3 1 0.5173 0.2854 0.1010 11.00000 0.05 0.23 Q4 1 -0.2093 0.6659 -0.0127 11.00000 0.05 0.19 Q5 1 -0.0737 0.5804 -0.0317 11.00000 0.05 0.18 Q6 1 -0.1849 0.5430 0.0241 11.00000 0.05 0.17 Q7 1 0.7817 0.0619 0.2439 11.00000 0.05 0.16 Q8 1 0.2881 0.8440 0.2537 11.00000 0.05 0.16 Q9 1 0.5080 0.1463 0.3598 11.00000 0.05 0.16 Q10 1 0.6407 0.2571 0.0954 11.00000 0.05 0.15 Q11 1 0.1010 0.8819 0.1246 11.00000 0.05 0.15 Q12 1 0.7781 0.1794 0.0485 11.00000 0.05 0.14 Q13 1 -0.1027 0.9064 0.1301 11.00000 0.05 0.14 Q14 1 0.5513 0.4297 0.1691 11.00000 0.05 0.14 Q15 1 0.6067 1.0093 0.3989 11.00000 0.05 0.14 Q16 1 0.7158 0.4870 0.3562 11.00000 0.05 0.14 Q17 1 0.7785 0.5396 0.4645 11.00000 0.05 0.14 Q18 1 0.3231 1.1778 -0.0004 11.00000 0.05 0.14 Q19 1 -0.0304 0.5944 0.1856 11.00000 0.05 0.14 Q20 1 0.7144 1.0345 0.4681 11.00000 0.05 0.14 ; _shelx_res_checksum 42117 _olex2_submission_special_instructions 'No special instructions were received' loop_ _space_group_symop_operation_xyz 'x, y, z' '-x, -y, -z' loop_ _atom_site_label _atom_site_type_symbol _atom_site_fract_x _atom_site_fract_y _atom_site_fract_z _atom_site_U_iso_or_equiv _atom_site_adp_type _atom_site_occupancy _atom_site_site_symmetry_order _atom_site_calc_flag _atom_site_refinement_flags_posn _atom_site_refinement_flags_adp _atom_site_refinement_flags_occupancy _atom_site_disorder_assembly _atom_site_disorder_group O1 O 0.34152(16) 0.49700(13) 0.31750(9) 0.0493(4) Uani 1 1 d . . . . . O2 O 0.60022(14) 0.36612(13) 0.24466(8) 0.0445(4) Uani 1 1 d . . . . . O3 O 0.47848(19) 0.10253(16) 0.19018(10) 0.0651(5) Uani 1 1 d . . . . . O4 O 0.64941(19) 0.13584(17) 0.27600(11) 0.0673(5) Uani 1 1 d . . . . . O5 O 0.6964(2) 0.24387(19) 0.13912(13) 0.0801(6) Uani 1 1 d . . . . . O6 O 0.5183(2) 0.24261(17) 0.06261(10) 0.0721(6) Uani 1 1 d . . . . . N1 N 0.23107(18) 0.30801(16) 0.29839(10) 0.0435(4) Uani 1 1 d . . . . . C1 C 0.0697(3) 0.1998(2) 0.33843(15) 0.0588(7) Uani 1 1 d . . . . . H1 H 0.099002 0.131094 0.318746 0.071 Uiso 1 1 calc R . . . . C2 C -0.0337(3) 0.1973(3) 0.37243(18) 0.0754(9) Uani 1 1 d . . . . . H2 H -0.072919 0.126228 0.375864 0.091 Uiso 1 1 calc R . . . . C3 C -0.0791(3) 0.2968(3) 0.40087(17) 0.0761(9) Uani 1 1 d . . . . . H3 H -0.150057 0.293635 0.422312 0.091 Uiso 1 1 calc R . . . . C4 C -0.0189(3) 0.4013(3) 0.39749(19) 0.0810(10) Uani 1 1 d . . . . . H4 H -0.047924 0.469652 0.417948 0.097 Uiso 1 1 calc R . . . . C5 C 0.0853(3) 0.4071(3) 0.36393(16) 0.0653(8) Uani 1 1 d . . . . . H5 H 0.125257 0.478576 0.361579 0.078 Uiso 1 1 calc R . . . . C6 C 0.1285(2) 0.3055(2) 0.33423(12) 0.0453(5) Uani 1 1 d . . . . . C7 C 0.3224(2) 0.39234(18) 0.29352(11) 0.0381(5) Uani 1 1 d . . . . . C8 C 0.38387(19) 0.30443(18) 0.24486(11) 0.0372(5) Uani 1 1 d . . . . . C9 C 0.2755(2) 0.21305(19) 0.25116(12) 0.0414(5) Uani 1 1 d . . . . . H9A H 0.214346 0.178093 0.207989 0.050 Uiso 1 1 calc R . . . . H9B H 0.306566 0.154137 0.273037 0.050 Uiso 1 1 calc R . . . . C10 C 0.3901(2) 0.3298(2) 0.17449(12) 0.0482(6) Uani 1 1 d . . . . . H10A H 0.342596 0.393237 0.168380 0.058 Uiso 1 1 calc R . . . . H10B H 0.354227 0.261481 0.136675 0.058 Uiso 1 1 calc R . . . . C11 C 0.5356(2) 0.3637(2) 0.17666(12) 0.0448(5) Uani 1 1 d . . . . . C12 C 0.5242(2) 0.29105(18) 0.27378(12) 0.0395(5) Uani 1 1 d . . . . . C13 C 0.5620(2) 0.32752(19) 0.35239(12) 0.0411(5) Uani 1 1 d . . . . . C14 C 0.5178(3) 0.2568(2) 0.39105(14) 0.0560(6) Uani 1 1 d . . . . . H14 H 0.468968 0.184719 0.368501 0.067 Uiso 1 1 calc R . . . . C15 C 0.5451(3) 0.2916(3) 0.46336(14) 0.0630(7) Uani 1 1 d . . . . . H15 H 0.515482 0.242364 0.488798 0.076 Uiso 1 1 calc R . . . . C16 C 0.6151(3) 0.3974(3) 0.49716(14) 0.0617(7) Uani 1 1 d . . . . . H16 H 0.631953 0.421288 0.545558 0.074 Uiso 1 1 calc R . . . . C17 C 0.6601(3) 0.4679(2) 0.45949(15) 0.0654(8) Uani 1 1 d . . . . . H17 H 0.709753 0.539422 0.482570 0.078 Uiso 1 1 calc R . . . . C18 C 0.6332(3) 0.4348(2) 0.38695(14) 0.0542(6) Uani 1 1 d . . . . . H18 H 0.662902 0.484673 0.361885 0.065 Uiso 1 1 calc R . . . . C19 C 0.5463(2) 0.1642(2) 0.24162(13) 0.0455(5) Uani 1 1 d . . . . . C20 C 0.6804(4) 0.0212(3) 0.2465(2) 0.0915(11) Uani 1 1 d . . . . . H20A H 0.696775 0.016982 0.200563 0.137 Uiso 1 1 calc GR . . . . H20B H 0.609100 -0.036753 0.244018 0.137 Uiso 1 1 calc GR . . . . H20C H 0.755825 0.007680 0.275409 0.137 Uiso 1 1 calc GR . . . . C21 C 0.5712(2) 0.4815(2) 0.16235(13) 0.0463(6) Uani 1 1 d . . . . . C22 C 0.6789(2) 0.5572(2) 0.20193(16) 0.0614(7) Uani 1 1 d . . . . . H22 H 0.727884 0.538640 0.239541 0.074 Uiso 1 1 calc R . . . . C23 C 0.7134(3) 0.6610(3) 0.1852(2) 0.0790(10) Uani 1 1 d . . . . . H23 H 0.785308 0.712099 0.212334 0.095 Uiso 1 1 calc R . . . . C24 C 0.6435(3) 0.6894(3) 0.12959(19) 0.0761(9) Uani 1 1 d . . . . . H24 H 0.668524 0.758564 0.118548 0.091 Uiso 1 1 calc R . . . . C25 C 0.5369(3) 0.6155(3) 0.09049(16) 0.0702(8) Uani 1 1 d . . . . . H25 H 0.488499 0.634722 0.052922 0.084 Uiso 1 1 calc R . . . . C26 C 0.5004(3) 0.5118(2) 0.10663(14) 0.0607(7) Uani 1 1 d . . . . . H26 H 0.427488 0.461957 0.079714 0.073 Uiso 1 1 calc R . . . . C27 C 0.5954(3) 0.2744(2) 0.12528(14) 0.0545(6) Uani 1 1 d . . . . . C28 C 0.5768(4) 0.1652(3) 0.01154(19) 0.1020(13) Uani 1 1 d . . . . . H28A H 0.523104 0.149447 -0.033848 0.153 Uiso 1 1 calc GR . . . . H28B H 0.584540 0.093369 0.024504 0.153 Uiso 1 1 calc GR . . . . H28C H 0.660864 0.202260 0.010748 0.153 Uiso 1 1 calc GR . . . . O7 O 0.32385(16) 0.99067(13) 0.31811(9) 0.0521(4) Uani 1 1 d . . . . . O8 O 0.05846(14) 0.80253(13) 0.19149(7) 0.0384(3) Uani 1 1 d . . . . . O9 O 0.16562(18) 0.56825(15) 0.15352(10) 0.0589(5) Uani 1 1 d . . . . . O10 O 0.01194(17) 0.56002(14) 0.21606(10) 0.0567(5) Uani 1 1 d . . . . . O11 O 0.11706(18) 0.69845(15) 0.02150(9) 0.0576(5) Uani 1 1 d . . . . . O12 O -0.06127(16) 0.68960(16) 0.06683(9) 0.0589(5) Uani 1 1 d . . . . . N2 N 0.43685(18) 0.82991(16) 0.31210(10) 0.0430(4) Uani 1 1 d . . . . . C29 C 0.6061(3) 0.7584(2) 0.37798(15) 0.0606(7) Uani 1 1 d . . . . . H29 H 0.586411 0.687213 0.344782 0.073 Uiso 1 1 calc R . . . . C30 C 0.7042(3) 0.7741(3) 0.43540(18) 0.0772(9) Uani 1 1 d . . . . . H30 H 0.750914 0.713628 0.440367 0.093 Uiso 1 1 calc R . . . . C31 C 0.7326(3) 0.8779(3) 0.48471(17) 0.0784(10) Uani 1 1 d . . . . . H31 H 0.797730 0.888107 0.523563 0.094 Uiso 1 1 calc R . . . . C32 C 0.6652(3) 0.9661(3) 0.47672(18) 0.0867(11) Uani 1 1 d . . . . . H32 H 0.684958 1.036962 0.510228 0.104 Uiso 1 1 calc R . . . . C33 C 0.5670(3) 0.9523(3) 0.41927(16) 0.0743(9) Uani 1 1 d . . . . . H33 H 0.521284 1.013283 0.414175 0.089 Uiso 1 1 calc R . . . . C34 C 0.5383(2) 0.8472(2) 0.37002(12) 0.0443(5) Uani 1 1 d . . . . . C35 C 0.3428(2) 0.89263(18) 0.29349(12) 0.0386(5) Uani 1 1 d . . . . . C36 C 0.2768(2) 0.79254(17) 0.23061(11) 0.0352(5) Uani 1 1 d . . . . . C37 C 0.3875(2) 0.72609(18) 0.25386(12) 0.0396(5) Uani 1 1 d . . . . . H37A H 0.358961 0.657239 0.268139 0.048 Uiso 1 1 calc R . . . . H37B H 0.444765 0.709242 0.221030 0.048 Uiso 1 1 calc R . . . . C38 C 0.2643(2) 0.8194(2) 0.15933(12) 0.0428(5) Uani 1 1 d . . . . . H38A H 0.294269 0.759452 0.126559 0.051 Uiso 1 1 calc R . . . . H38B H 0.314288 0.893932 0.163015 0.051 Uiso 1 1 calc R . . . . C39 C 0.1192(2) 0.82220(18) 0.13587(11) 0.0374(5) Uani 1 1 d . . . . . C40 C 0.1372(2) 0.74523(17) 0.23372(11) 0.0353(5) Uani 1 1 d . . . . . C41 C 0.1039(2) 0.77304(18) 0.30574(11) 0.0361(5) Uani 1 1 d . . . . . C42 C 0.0211(2) 0.8525(2) 0.32337(13) 0.0494(6) Uani 1 1 d . . . . . H42 H -0.014173 0.890899 0.291148 0.059 Uiso 1 1 calc R . . . . C43 C -0.0095(3) 0.8751(2) 0.38922(15) 0.0635(7) Uani 1 1 d . . . . . H43 H -0.067042 0.927087 0.400512 0.076 Uiso 1 1 calc R . . . . C44 C 0.0445(3) 0.8212(3) 0.43768(14) 0.0639(7) Uani 1 1 d . . . . . H44 H 0.024744 0.837394 0.481940 0.077 Uiso 1 1 calc R . . . . C45 C 0.1277(3) 0.7435(3) 0.42060(14) 0.0612(7) Uani 1 1 d . . . . . H45 H 0.164181 0.706431 0.453263 0.073 Uiso 1 1 calc R . . . . C46 C 0.1579(2) 0.7199(2) 0.35489(13) 0.0498(6) Uani 1 1 d . . . . . H46 H 0.215196 0.667468 0.343858 0.060 Uiso 1 1 calc R . . . . C47 C 0.1091(2) 0.61404(18) 0.19675(12) 0.0398(5) Uani 1 1 d . . . . . C48 C -0.0265(3) 0.4370(2) 0.18067(18) 0.0753(9) Uani 1 1 d . . . . . H48A H -0.066766 0.429231 0.133168 0.113 Uiso 1 1 calc GR . . . . H48B H -0.086419 0.402885 0.203736 0.113 Uiso 1 1 calc GR . . . . H48C H 0.048387 0.397967 0.181788 0.113 Uiso 1 1 calc GR . . . . C49 C 0.0612(2) 0.72782(18) 0.06815(12) 0.0417(5) Uani 1 1 d . . . . . C50 C -0.1322(3) 0.6067(3) 0.00390(16) 0.0772(9) Uani 1 1 d . . . . . H50A H -0.124841 0.637216 -0.035560 0.116 Uiso 1 1 calc GR . . . . H50B H -0.221529 0.593283 0.007003 0.116 Uiso 1 1 calc GR . . . . H50C H -0.097270 0.534659 -0.001434 0.116 Uiso 1 1 calc GR . . . . C51 C 0.0849(2) 0.93630(19) 0.12112(11) 0.0415(5) Uani 1 1 d . . . . . C52 C -0.0168(3) 0.9854(2) 0.14428(14) 0.0562(6) Uani 1 1 d . . . . . H52 H -0.063659 0.950328 0.170981 0.067 Uiso 1 1 calc R . . . . C53 C -0.0502(3) 1.0867(2) 0.12825(16) 0.0682(8) Uani 1 1 d . . . . . H53 H -0.118141 1.119745 0.145059 0.082 Uiso 1 1 calc R . . . . C54 C 0.0161(3) 1.1384(2) 0.08788(15) 0.0662(8) Uani 1 1 d . . . . . H54 H -0.007228 1.205720 0.076711 0.079 Uiso 1 1 calc R . . . . C55 C 0.1172(3) 1.0897(2) 0.06411(13) 0.0611(7) Uani 1 1 d . . . . . H55 H 0.162519 1.124381 0.036653 0.073 Uiso 1 1 calc R . . . . C56 C 0.1526(3) 0.9894(2) 0.08052(12) 0.0499(6) Uani 1 1 d . . . . . H56 H 0.221823 0.957596 0.064395 0.060 Uiso 1 1 calc R . . . . loop_ _atom_site_aniso_label _atom_site_aniso_U_11 _atom_site_aniso_U_22 _atom_site_aniso_U_33 _atom_site_aniso_U_23 _atom_site_aniso_U_13 _atom_site_aniso_U_12 O1 0.0543(9) 0.0341(9) 0.0604(11) 0.0119(7) 0.0143(8) 0.0067(7) O2 0.0389(8) 0.0472(9) 0.0486(9) 0.0162(7) 0.0095(7) 0.0003(6) O3 0.0701(12) 0.0483(10) 0.0655(13) -0.0049(9) 0.0106(10) 0.0067(9) O4 0.0665(12) 0.0578(11) 0.0751(14) 0.0094(10) 0.0071(10) 0.0273(9) O5 0.0716(14) 0.0782(14) 0.0978(17) 0.0152(12) 0.0366(12) 0.0287(11) O6 0.0985(16) 0.0605(12) 0.0545(12) 0.0042(9) 0.0234(11) 0.0095(11) N1 0.0421(10) 0.0363(10) 0.0524(12) 0.0100(8) 0.0162(9) -0.0006(8) C1 0.0578(15) 0.0589(16) 0.0657(17) 0.0231(13) 0.0229(13) 0.0011(12) C2 0.0667(18) 0.090(2) 0.084(2) 0.0432(19) 0.0318(17) 0.0001(16) C3 0.0579(17) 0.113(3) 0.074(2) 0.0420(19) 0.0328(16) 0.0172(17) C4 0.074(2) 0.090(2) 0.094(3) 0.0239(19) 0.0440(19) 0.0307(17) C5 0.0605(16) 0.0596(17) 0.081(2) 0.0153(15) 0.0309(15) 0.0107(13) C6 0.0404(11) 0.0550(14) 0.0420(13) 0.0160(11) 0.0097(10) 0.0019(10) C7 0.0392(11) 0.0345(12) 0.0410(12) 0.0136(9) 0.0039(9) 0.0038(8) C8 0.0356(10) 0.0371(11) 0.0371(12) 0.0107(9) 0.0044(9) -0.0013(8) C9 0.0398(11) 0.0360(11) 0.0451(13) 0.0059(10) 0.0096(10) -0.0011(9) C10 0.0463(13) 0.0549(14) 0.0417(13) 0.0147(11) 0.0068(10) -0.0041(10) C11 0.0475(12) 0.0444(13) 0.0424(13) 0.0102(10) 0.0133(10) 0.0004(10) C12 0.0388(11) 0.0361(11) 0.0443(13) 0.0119(9) 0.0093(10) 0.0025(8) C13 0.0386(11) 0.0396(12) 0.0443(13) 0.0109(10) 0.0040(10) 0.0083(9) C14 0.0596(15) 0.0551(15) 0.0489(15) 0.0153(12) 0.0038(12) -0.0063(12) C15 0.0672(17) 0.076(2) 0.0484(16) 0.0243(14) 0.0087(13) 0.0064(14) C16 0.0708(17) 0.0712(19) 0.0421(14) 0.0095(13) 0.0052(13) 0.0274(14) C17 0.0801(19) 0.0470(15) 0.0546(17) 0.0014(13) -0.0083(14) 0.0057(13) C18 0.0662(16) 0.0410(13) 0.0519(15) 0.0127(11) 0.0028(13) 0.0047(11) C19 0.0466(12) 0.0392(12) 0.0526(15) 0.0115(11) 0.0160(11) 0.0050(10) C20 0.098(3) 0.067(2) 0.112(3) 0.0120(19) 0.023(2) 0.0475(18) C21 0.0510(13) 0.0424(13) 0.0464(14) 0.0072(10) 0.0205(11) 0.0034(10) C22 0.0492(14) 0.0551(16) 0.078(2) 0.0172(14) 0.0122(13) 0.0005(12) C23 0.0658(18) 0.0553(18) 0.112(3) 0.0223(18) 0.0183(19) -0.0119(14) C24 0.096(2) 0.0507(17) 0.095(2) 0.0289(17) 0.044(2) 0.0044(16) C25 0.104(2) 0.0580(17) 0.0568(17) 0.0261(14) 0.0247(17) 0.0096(16) C26 0.0776(18) 0.0522(15) 0.0487(16) 0.0128(12) 0.0106(14) -0.0044(13) C27 0.0665(17) 0.0436(14) 0.0546(16) 0.0142(12) 0.0185(13) -0.0008(12) C28 0.155(4) 0.074(2) 0.079(2) -0.0034(19) 0.056(3) 0.024(2) O7 0.0600(10) 0.0307(8) 0.0599(11) 0.0069(7) 0.0032(8) 0.0044(7) O8 0.0399(7) 0.0422(8) 0.0350(8) 0.0136(6) 0.0067(6) 0.0071(6) O9 0.0667(11) 0.0450(10) 0.0577(11) -0.0056(8) 0.0228(9) 0.0013(8) O10 0.0597(10) 0.0348(9) 0.0700(12) 0.0015(8) 0.0232(9) -0.0086(7) O11 0.0735(12) 0.0536(10) 0.0424(10) 0.0026(8) 0.0168(9) 0.0074(9) O12 0.0523(10) 0.0588(11) 0.0497(10) -0.0069(8) 0.0026(8) -0.0047(8) N2 0.0454(10) 0.0361(10) 0.0415(11) 0.0055(8) -0.0014(8) 0.0056(8) C29 0.0532(14) 0.0549(16) 0.0682(18) 0.0194(13) -0.0053(13) 0.0021(12) C30 0.0575(17) 0.081(2) 0.090(2) 0.038(2) -0.0126(17) 0.0044(15) C31 0.0533(16) 0.114(3) 0.0594(19) 0.0267(19) -0.0093(14) -0.0059(17) C32 0.071(2) 0.094(3) 0.065(2) -0.0147(18) -0.0157(17) 0.0012(18) C33 0.0682(18) 0.0637(18) 0.070(2) -0.0063(15) -0.0136(15) 0.0116(14) C34 0.0393(11) 0.0471(13) 0.0450(13) 0.0144(11) 0.0031(10) 0.0010(9) C35 0.0411(11) 0.0315(11) 0.0424(12) 0.0111(9) 0.0055(9) 0.0016(8) C36 0.0386(10) 0.0282(10) 0.0386(12) 0.0088(8) 0.0071(9) 0.0039(8) C37 0.0406(11) 0.0338(11) 0.0430(12) 0.0088(9) 0.0058(9) 0.0045(8) C38 0.0442(12) 0.0445(12) 0.0421(13) 0.0154(10) 0.0100(10) 0.0039(9) C39 0.0455(11) 0.0362(11) 0.0314(11) 0.0110(9) 0.0071(9) 0.0050(9) C40 0.0377(10) 0.0314(11) 0.0358(11) 0.0086(9) 0.0048(9) 0.0037(8) C41 0.0410(11) 0.0317(10) 0.0347(11) 0.0081(9) 0.0071(9) 0.0013(8) C42 0.0627(15) 0.0479(13) 0.0440(14) 0.0166(11) 0.0161(12) 0.0175(11) C43 0.0805(19) 0.0650(17) 0.0575(17) 0.0175(14) 0.0336(15) 0.0314(14) C44 0.0799(19) 0.078(2) 0.0395(14) 0.0159(13) 0.0225(14) 0.0209(15) C45 0.0722(17) 0.0789(19) 0.0428(14) 0.0271(13) 0.0158(13) 0.0244(14) C46 0.0571(14) 0.0536(14) 0.0461(14) 0.0194(11) 0.0156(11) 0.0177(11) C47 0.0437(11) 0.0334(11) 0.0401(12) 0.0093(9) 0.0051(10) 0.0009(9) C48 0.082(2) 0.0380(14) 0.093(2) -0.0025(14) 0.0199(18) -0.0160(13) C49 0.0526(13) 0.0313(11) 0.0394(13) 0.0089(9) 0.0043(10) 0.0058(9) C50 0.0700(19) 0.070(2) 0.065(2) -0.0104(15) -0.0088(15) -0.0109(15) C51 0.0523(12) 0.0338(11) 0.0331(11) 0.0055(9) -0.0008(10) 0.0036(9) C52 0.0617(15) 0.0517(15) 0.0584(16) 0.0186(12) 0.0091(13) 0.0171(12) C53 0.0758(19) 0.0567(17) 0.075(2) 0.0198(15) 0.0073(16) 0.0298(14) C54 0.101(2) 0.0391(14) 0.0515(16) 0.0143(12) -0.0107(16) 0.0159(14) C55 0.095(2) 0.0410(14) 0.0393(14) 0.0110(11) -0.0022(14) -0.0023(14) C56 0.0695(16) 0.0395(12) 0.0391(13) 0.0102(10) 0.0078(12) 0.0046(11) loop_ _atom_type_symbol _atom_type_description _atom_type_scat_dispersion_real _atom_type_scat_dispersion_imag _atom_type_scat_source C C 0.0181 0.0091 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' N N 0.0311 0.0180 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' O O 0.0492 0.0322 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' loop_ _geom_angle_atom_site_label_1 _geom_angle_atom_site_label_2 _geom_angle_atom_site_label_3 _geom_angle _geom_angle_site_symmetry_1 _geom_angle_site_symmetry_3 _geom_angle_publ_flag C11 O2 C12 109.78(16) . . ? C19 O4 C20 115.4(2) . . ? C27 O6 C28 111.3(3) . . ? C6 N1 C9 130.11(18) . . ? C7 N1 C6 135.0(2) . . ? C7 N1 C9 94.90(17) . . ? C2 C1 H1 120.5 . . ? C6 C1 H1 120.5 . . ? C6 C1 C2 119.1(3) . . ? C1 C2 H2 119.3 . . ? C3 C2 C1 121.4(3) . . ? C3 C2 H2 119.3 . . ? C2 C3 H3 120.4 . . ? C2 C3 C4 119.1(3) . . ? C4 C3 H3 120.4 . . ? C3 C4 H4 119.5 . . ? C3 C4 C5 121.0(3) . . ? C5 C4 H4 119.5 . . ? C4 C5 H5 120.4 . . ? C6 C5 C4 119.2(3) . . ? C6 C5 H5 120.4 . . ? C1 C6 N1 119.2(2) . . ? C5 C6 N1 120.6(2) . . ? C5 C6 C1 120.2(2) . . ? O1 C7 N1 132.3(2) . . ? O1 C7 C8 135.4(2) . . ? N1 C7 C8 92.26(16) . . ? C7 C8 C9 85.22(16) . . ? C7 C8 C12 115.47(17) . . ? C10 C8 C7 114.85(19) . . ? C10 C8 C9 120.17(18) . . ? C10 C8 C12 104.04(18) . . ? C12 C8 C9 117.05(19) . . ? N1 C9 C8 87.60(15) . . ? N1 C9 H9A 114.1 . . ? N1 C9 H9B 114.1 . . ? C8 C9 H9A 114.1 . . ? C8 C9 H9B 114.1 . . ? H9A C9 H9B 111.2 . . ? C8 C10 H10A 110.8 . . ? C8 C10 H10B 110.8 . . ? C8 C10 C11 104.86(19) . . ? H10A C10 H10B 108.9 . . ? C11 C10 H10A 110.8 . . ? C11 C10 H10B 110.8 . . ? O2 C11 C10 106.20(18) . . ? O2 C11 C21 108.76(18) . . ? O2 C11 C27 106.2(2) . . ? C10 C11 C27 114.7(2) . . ? C21 C11 C10 114.9(2) . . ? C21 C11 C27 105.71(18) . . ? O2 C12 C8 103.53(17) . . ? O2 C12 C13 109.68(17) . . ? O2 C12 C19 106.95(17) . . ? C8 C12 C19 108.42(18) . . ? C13 C12 C8 114.36(18) . . ? C13 C12 C19 113.22(19) . . ? C14 C13 C12 119.9(2) . . ? C14 C13 C18 118.6(2) . . ? C18 C13 C12 121.3(2) . . ? C13 C14 H14 119.6 . . ? C13 C14 C15 120.8(2) . . ? C15 C14 H14 119.6 . . ? C14 C15 H15 119.8 . . ? C16 C15 C14 120.3(3) . . ? C16 C15 H15 119.8 . . ? C15 C16 H16 120.3 . . ? C15 C16 C17 119.4(3) . . ? C17 C16 H16 120.3 . . ? C16 C17 H17 119.5 . . ? C16 C17 C18 121.1(3) . . ? C18 C17 H17 119.5 . . ? C13 C18 C17 119.7(3) . . ? C13 C18 H18 120.2 . . ? C17 C18 H18 120.2 . . ? O3 C19 O4 124.7(2) . . ? O3 C19 C12 122.9(2) . . ? O4 C19 C12 112.3(2) . . ? O4 C20 H20A 109.5 . . ? O4 C20 H20B 109.5 . . ? O4 C20 H20C 109.5 . . ? H20A C20 H20B 109.5 . . ? H20A C20 H20C 109.5 . . ? H20B C20 H20C 109.5 . . ? C22 C21 C11 120.9(2) . . ? C22 C21 C26 118.7(2) . . ? C26 C21 C11 120.4(2) . . ? C21 C22 H22 120.2 . . ? C21 C22 C23 119.7(3) . . ? C23 C22 H22 120.2 . . ? C22 C23 H23 119.4 . . ? C24 C23 C22 121.1(3) . . ? C24 C23 H23 119.4 . . ? C23 C24 H24 120.2 . . ? C25 C24 C23 119.6(3) . . ? C25 C24 H24 120.2 . . ? C24 C25 H25 119.9 . . ? C24 C25 C26 120.1(3) . . ? C26 C25 H25 119.9 . . ? C21 C26 C25 120.8(3) . . ? C21 C26 H26 119.6 . . ? C25 C26 H26 119.6 . . ? O5 C27 O6 125.1(3) . . ? O5 C27 C11 124.9(3) . . ? O6 C27 C11 110.0(2) . . ? O6 C28 H28A 109.5 . . ? O6 C28 H28B 109.5 . . ? O6 C28 H28C 109.5 . . ? H28A C28 H28B 109.5 . . ? H28A C28 H28C 109.5 . . ? H28B C28 H28C 109.5 . . ? C40 O8 C39 110.38(16) . . ? C47 O10 C48 116.0(2) . . ? C49 O12 C50 117.4(2) . . ? C34 N2 C37 130.08(19) . . ? C35 N2 C34 134.43(19) . . ? C35 N2 C37 95.11(16) . . ? C30 C29 H29 119.9 . . ? C34 C29 H29 119.9 . . ? C34 C29 C30 120.1(3) . . ? C29 C30 H30 119.9 . . ? C31 C30 C29 120.2(3) . . ? C31 C30 H30 119.9 . . ? C30 C31 H31 120.2 . . ? C32 C31 C30 119.6(3) . . ? C32 C31 H31 120.2 . . ? C31 C32 H32 119.5 . . ? C31 C32 C33 121.0(3) . . ? C33 C32 H32 119.5 . . ? C32 C33 H33 120.4 . . ? C34 C33 C32 119.1(3) . . ? C34 C33 H33 120.4 . . ? C29 C34 N2 119.8(2) . . ? C29 C34 C33 119.9(2) . . ? C33 C34 N2 120.2(2) . . ? O7 C35 N2 132.2(2) . . ? O7 C35 C36 135.6(2) . . ? N2 C35 C36 92.14(17) . . ? C35 C36 C37 85.46(16) . . ? C35 C36 C40 113.97(17) . . ? C38 C36 C35 116.09(17) . . ? C38 C36 C37 118.81(18) . . ? C38 C36 C40 104.18(17) . . ? C40 C36 C37 118.24(17) . . ? N2 C37 C36 87.28(16) . . ? N2 C37 H37A 114.1 . . ? N2 C37 H37B 114.1 . . ? C36 C37 H37A 114.1 . . ? C36 C37 H37B 114.1 . . ? H37A C37 H37B 111.3 . . ? C36 C38 H38A 110.7 . . ? C36 C38 H38B 110.7 . . ? C36 C38 C39 105.09(17) . . ? H38A C38 H38B 108.8 . . ? C39 C38 H38A 110.7 . . ? C39 C38 H38B 110.7 . . ? O8 C39 C38 106.33(17) . . ? O8 C39 C49 110.21(17) . . ? O8 C39 C51 108.05(17) . . ? C49 C39 C38 111.64(18) . . ? C51 C39 C38 115.33(18) . . ? C51 C39 C49 105.24(18) . . ? O8 C40 C36 103.82(16) . . ? O8 C40 C41 108.17(17) . . ? O8 C40 C47 106.78(16) . . ? C41 C40 C36 115.22(17) . . ? C41 C40 C47 113.10(17) . . ? C47 C40 C36 109.00(17) . . ? C42 C41 C40 121.1(2) . . ? C46 C41 C40 119.9(2) . . ? C46 C41 C42 119.0(2) . . ? C41 C42 H42 120.0 . . ? C41 C42 C43 120.0(2) . . ? C43 C42 H42 120.0 . . ? C42 C43 H43 119.8 . . ? C44 C43 C42 120.5(3) . . ? C44 C43 H43 119.8 . . ? C43 C44 H44 120.2 . . ? C45 C44 C43 119.6(2) . . ? C45 C44 H44 120.2 . . ? C44 C45 H45 119.9 . . ? C44 C45 C46 120.2(3) . . ? C46 C45 H45 119.9 . . ? C41 C46 C45 120.7(2) . . ? C41 C46 H46 119.7 . . ? C45 C46 H46 119.7 . . ? O9 C47 O10 124.3(2) . . ? O9 C47 C40 123.4(2) . . ? O10 C47 C40 112.22(18) . . ? O10 C48 H48A 109.5 . . ? O10 C48 H48B 109.5 . . ? O10 C48 H48C 109.5 . . ? H48A C48 H48B 109.5 . . ? H48A C48 H48C 109.5 . . ? H48B C48 H48C 109.5 . . ? O11 C49 O12 124.8(2) . . ? O11 C49 C39 124.2(2) . . ? O12 C49 C39 110.86(19) . . ? O12 C50 H50A 109.5 . . ? O12 C50 H50B 109.5 . . ? O12 C50 H50C 109.5 . . ? H50A C50 H50B 109.5 . . ? H50A C50 H50C 109.5 . . ? H50B C50 H50C 109.5 . . ? C52 C51 C39 121.2(2) . . ? C52 C51 C56 118.7(2) . . ? C56 C51 C39 120.0(2) . . ? C51 C52 H52 119.7 . . ? C51 C52 C53 120.7(3) . . ? C53 C52 H52 119.7 . . ? C52 C53 H53 119.7 . . ? C54 C53 C52 120.5(3) . . ? C54 C53 H53 119.7 . . ? C53 C54 H54 120.4 . . ? C53 C54 C55 119.2(3) . . ? C55 C54 H54 120.4 . . ? C54 C55 H55 119.6 . . ? C54 C55 C56 120.8(3) . . ? C56 C55 H55 119.6 . . ? C51 C56 H56 120.0 . . ? C55 C56 C51 120.1(3) . . ? C55 C56 H56 120.0 . . ? loop_ _geom_bond_atom_site_label_1 _geom_bond_atom_site_label_2 _geom_bond_distance _geom_bond_site_symmetry_2 _geom_bond_publ_flag O1 C7 1.212(3) . ? O2 C11 1.419(3) . ? O2 C12 1.435(3) . ? O3 C19 1.193(3) . ? O4 C19 1.313(3) . ? O4 C20 1.451(3) . ? O5 C27 1.177(3) . ? O6 C27 1.334(3) . ? O6 C28 1.475(4) . ? N1 C6 1.404(3) . ? N1 C7 1.359(3) . ? N1 C9 1.470(3) . ? C1 H1 0.9300 . ? C1 C2 1.388(4) . ? C1 C6 1.379(3) . ? C2 H2 0.9300 . ? C2 C3 1.362(5) . ? C3 H3 0.9300 . ? C3 C4 1.366(5) . ? C4 H4 0.9300 . ? C4 C5 1.392(4) . ? C5 H5 0.9300 . ? C5 C6 1.377(4) . ? C7 C8 1.533(3) . ? C8 C9 1.547(3) . ? C8 C10 1.528(3) . ? C8 C12 1.544(3) . ? C9 H9A 0.9700 . ? C9 H9B 0.9700 . ? C10 H10A 0.9700 . ? C10 H10B 0.9700 . ? C10 C11 1.548(3) . ? C11 C21 1.525(3) . ? C11 C27 1.563(3) . ? C12 C13 1.513(3) . ? C12 C19 1.558(3) . ? C13 C14 1.375(3) . ? C13 C18 1.383(3) . ? C14 H14 0.9300 . ? C14 C15 1.389(4) . ? C15 H15 0.9300 . ? C15 C16 1.361(4) . ? C16 H16 0.9300 . ? C16 C17 1.362(4) . ? C17 H17 0.9300 . ? C17 C18 1.393(4) . ? C18 H18 0.9300 . ? C20 H20A 0.9600 . ? C20 H20B 0.9600 . ? C20 H20C 0.9600 . ? C21 C22 1.382(3) . ? C21 C26 1.386(4) . ? C22 H22 0.9300 . ? C22 C23 1.390(4) . ? C23 H23 0.9300 . ? C23 C24 1.370(5) . ? C24 H24 0.9300 . ? C24 C25 1.363(4) . ? C25 H25 0.9300 . ? C25 C26 1.387(4) . ? C26 H26 0.9300 . ? C28 H28A 0.9600 . ? C28 H28B 0.9600 . ? C28 H28C 0.9600 . ? O7 C35 1.210(3) . ? O8 C39 1.435(2) . ? O8 C40 1.429(3) . ? O9 C47 1.196(3) . ? O10 C47 1.322(3) . ? O10 C48 1.457(3) . ? O11 C49 1.194(3) . ? O12 C49 1.328(3) . ? O12 C50 1.449(3) . ? N2 C34 1.411(3) . ? N2 C35 1.361(3) . ? N2 C37 1.473(3) . ? C29 H29 0.9300 . ? C29 C30 1.385(4) . ? C29 C34 1.364(4) . ? C30 H30 0.9300 . ? C30 C31 1.365(5) . ? C31 H31 0.9300 . ? C31 C32 1.355(5) . ? C32 H32 0.9300 . ? C32 C33 1.389(4) . ? C33 H33 0.9300 . ? C33 C34 1.375(4) . ? C35 C36 1.534(3) . ? C36 C37 1.551(3) . ? C36 C38 1.531(3) . ? C36 C40 1.549(3) . ? C37 H37A 0.9700 . ? C37 H37B 0.9700 . ? C38 H38A 0.9700 . ? C38 H38B 0.9700 . ? C38 C39 1.540(3) . ? C39 C49 1.540(3) . ? C39 C51 1.526(3) . ? C40 C41 1.518(3) . ? C40 C47 1.543(3) . ? C41 C42 1.381(3) . ? C41 C46 1.375(3) . ? C42 H42 0.9300 . ? C42 C43 1.389(3) . ? C43 H43 0.9300 . ? C43 C44 1.370(4) . ? C44 H44 0.9300 . ? C44 C45 1.368(4) . ? C45 H45 0.9300 . ? C45 C46 1.384(3) . ? C46 H46 0.9300 . ? C48 H48A 0.9600 . ? C48 H48B 0.9600 . ? C48 H48C 0.9600 . ? C50 H50A 0.9600 . ? C50 H50B 0.9600 . ? C50 H50C 0.9600 . ? C51 C52 1.373(3) . ? C51 C56 1.391(3) . ? C52 H52 0.9300 . ? C52 C53 1.387(4) . ? C53 H53 0.9300 . ? C53 C54 1.369(4) . ? C54 H54 0.9300 . ? C54 C55 1.371(4) . ? C55 H55 0.9300 . ? C55 C56 1.384(4) . ? C56 H56 0.9300 . ? loop_ _geom_torsion_atom_site_label_1 _geom_torsion_atom_site_label_2 _geom_torsion_atom_site_label_3 _geom_torsion_atom_site_label_4 _geom_torsion _geom_torsion_site_symmetry_1 _geom_torsion_site_symmetry_2 _geom_torsion_site_symmetry_3 _geom_torsion_site_symmetry_4 _geom_torsion_publ_flag O1 C7 C8 C9 -176.4(3) . . . . ? O1 C7 C8 C10 -55.2(3) . . . . ? O1 C7 C8 C12 65.9(3) . . . . ? O2 C11 C21 C22 18.2(3) . . . . ? O2 C11 C21 C26 -165.6(2) . . . . ? O2 C11 C27 O5 -20.2(3) . . . . ? O2 C11 C27 O6 162.94(19) . . . . ? O2 C12 C13 C14 -169.1(2) . . . . ? O2 C12 C13 C18 15.5(3) . . . . ? O2 C12 C19 O3 -92.2(3) . . . . ? O2 C12 C19 O4 85.4(2) . . . . ? N1 C7 C8 C9 1.25(18) . . . . ? N1 C7 C8 C10 122.38(19) . . . . ? N1 C7 C8 C12 -116.50(19) . . . . ? C1 C2 C3 C4 -1.9(5) . . . . ? C2 C1 C6 N1 -178.4(3) . . . . ? C2 C1 C6 C5 0.5(4) . . . . ? C2 C3 C4 C5 1.8(6) . . . . ? C3 C4 C5 C6 -0.5(5) . . . . ? C4 C5 C6 N1 178.3(3) . . . . ? C4 C5 C6 C1 -0.6(5) . . . . ? C6 N1 C7 O1 -3.5(5) . . . . ? C6 N1 C7 C8 178.7(3) . . . . ? C6 N1 C9 C8 -178.7(2) . . . . ? C6 C1 C2 C3 0.8(5) . . . . ? C7 N1 C6 C1 -166.9(3) . . . . ? C7 N1 C6 C5 14.2(4) . . . . ? C7 N1 C9 C8 1.30(19) . . . . ? C7 C8 C9 N1 -1.15(16) . . . . ? C7 C8 C10 C11 111.6(2) . . . . ? C7 C8 C12 O2 -96.6(2) . . . . ? C7 C8 C12 C13 22.7(3) . . . . ? C7 C8 C12 C19 150.10(18) . . . . ? C8 C10 C11 O2 -4.6(2) . . . . ? C8 C10 C11 C21 -124.9(2) . . . . ? C8 C10 C11 C27 112.3(2) . . . . ? C8 C12 C13 C14 75.1(3) . . . . ? C8 C12 C13 C18 -100.3(3) . . . . ? C8 C12 C19 O3 18.8(3) . . . . ? C8 C12 C19 O4 -163.5(2) . . . . ? C9 N1 C6 C1 13.1(4) . . . . ? C9 N1 C6 C5 -165.8(3) . . . . ? C9 N1 C7 O1 176.4(3) . . . . ? C9 N1 C7 C8 -1.31(19) . . . . ? C9 C8 C10 C11 -149.0(2) . . . . ? C9 C8 C12 O2 165.42(18) . . . . ? C9 C8 C12 C13 -75.3(2) . . . . ? C9 C8 C12 C19 52.1(2) . . . . ? C10 C8 C9 N1 -117.2(2) . . . . ? C10 C8 C12 O2 30.2(2) . . . . ? C10 C8 C12 C13 149.52(19) . . . . ? C10 C8 C12 C19 -83.1(2) . . . . ? C10 C11 C21 C22 137.1(2) . . . . ? C10 C11 C21 C26 -46.7(3) . . . . ? C10 C11 C27 O5 -137.1(3) . . . . ? C10 C11 C27 O6 46.0(3) . . . . ? C11 O2 C12 C8 -35.2(2) . . . . ? C11 O2 C12 C13 -157.65(18) . . . . ? C11 O2 C12 C19 79.2(2) . . . . ? C11 C21 C22 C23 176.3(3) . . . . ? C11 C21 C26 C25 -175.9(2) . . . . ? C12 O2 C11 C10 25.3(2) . . . . ? C12 O2 C11 C21 149.54(18) . . . . ? C12 O2 C11 C27 -97.13(19) . . . . ? C12 C8 C9 N1 115.1(2) . . . . ? C12 C8 C10 C11 -15.5(2) . . . . ? C12 C13 C14 C15 -176.2(2) . . . . ? C12 C13 C18 C17 176.5(2) . . . . ? C13 C12 C19 O3 146.8(2) . . . . ? C13 C12 C19 O4 -35.5(3) . . . . ? C13 C14 C15 C16 0.8(5) . . . . ? C14 C13 C18 C17 1.0(4) . . . . ? C14 C15 C16 C17 -1.2(5) . . . . ? C15 C16 C17 C18 1.6(5) . . . . ? C16 C17 C18 C13 -1.5(4) . . . . ? C18 C13 C14 C15 -0.7(4) . . . . ? C19 C12 C13 C14 -49.7(3) . . . . ? C19 C12 C13 C18 134.8(2) . . . . ? C20 O4 C19 O3 1.2(4) . . . . ? C20 O4 C19 C12 -176.4(2) . . . . ? C21 C11 C27 O5 95.2(3) . . . . ? C21 C11 C27 O6 -81.6(2) . . . . ? C21 C22 C23 C24 -0.8(5) . . . . ? C22 C21 C26 C25 0.4(4) . . . . ? C22 C23 C24 C25 1.1(5) . . . . ? C23 C24 C25 C26 -0.6(5) . . . . ? C24 C25 C26 C21 -0.1(5) . . . . ? C26 C21 C22 C23 0.1(4) . . . . ? C27 C11 C21 C22 -95.4(3) . . . . ? C27 C11 C21 C26 80.8(3) . . . . ? C28 O6 C27 O5 -1.2(4) . . . . ? C28 O6 C27 C11 175.7(2) . . . . ? O7 C35 C36 C37 178.1(3) . . . . ? O7 C35 C36 C38 58.1(3) . . . . ? O7 C35 C36 C40 -63.0(3) . . . . ? O8 C39 C49 O11 -154.2(2) . . . . ? O8 C39 C49 O12 30.0(3) . . . . ? O8 C39 C51 C52 -17.4(3) . . . . ? O8 C39 C51 C56 165.99(19) . . . . ? O8 C40 C41 C42 -6.7(3) . . . . ? O8 C40 C41 C46 174.11(19) . . . . ? O8 C40 C47 O9 88.1(3) . . . . ? O8 C40 C47 O10 -89.0(2) . . . . ? N2 C35 C36 C37 -0.70(17) . . . . ? N2 C35 C36 C38 -120.66(19) . . . . ? N2 C35 C36 C40 118.26(19) . . . . ? C29 C30 C31 C32 -0.8(5) . . . . ? C30 C29 C34 N2 -178.8(3) . . . . ? C30 C29 C34 C33 -0.3(4) . . . . ? C30 C31 C32 C33 0.4(6) . . . . ? C31 C32 C33 C34 0.1(6) . . . . ? C32 C33 C34 N2 178.4(3) . . . . ? C32 C33 C34 C29 -0.1(5) . . . . ? C34 N2 C35 O7 8.8(5) . . . . ? C34 N2 C35 C36 -172.4(2) . . . . ? C34 N2 C37 C36 172.9(2) . . . . ? C34 C29 C30 C31 0.8(5) . . . . ? C35 N2 C34 C29 170.4(3) . . . . ? C35 N2 C34 C33 -8.1(4) . . . . ? C35 N2 C37 C36 -0.73(18) . . . . ? C35 C36 C37 N2 0.65(16) . . . . ? C35 C36 C38 C39 -109.6(2) . . . . ? C35 C36 C40 O8 98.0(2) . . . . ? C35 C36 C40 C41 -20.0(3) . . . . ? C35 C36 C40 C47 -148.43(18) . . . . ? C36 C38 C39 O8 1.9(2) . . . . ? C36 C38 C39 C49 -118.31(19) . . . . ? C36 C38 C39 C51 121.65(19) . . . . ? C36 C40 C41 C42 108.9(2) . . . . ? C36 C40 C41 C46 -70.3(3) . . . . ? C36 C40 C47 O9 -23.5(3) . . . . ? C36 C40 C47 O10 159.41(19) . . . . ? C37 N2 C34 C29 -0.6(4) . . . . ? C37 N2 C34 C33 -179.1(3) . . . . ? C37 N2 C35 O7 -178.1(3) . . . . ? C37 N2 C35 C36 0.74(18) . . . . ? C37 C36 C38 C39 150.70(18) . . . . ? C37 C36 C40 O8 -163.88(17) . . . . ? C37 C36 C40 C41 78.0(2) . . . . ? C37 C36 C40 C47 -50.4(2) . . . . ? C38 C36 C37 N2 118.03(19) . . . . ? C38 C36 C40 O8 -29.5(2) . . . . ? C38 C36 C40 C41 -147.55(18) . . . . ? C38 C36 C40 C47 84.1(2) . . . . ? C38 C39 C49 O11 -36.2(3) . . . . ? C38 C39 C49 O12 147.9(2) . . . . ? C38 C39 C51 C52 -136.1(2) . . . . ? C38 C39 C51 C56 47.2(3) . . . . ? C39 O8 C40 C36 32.5(2) . . . . ? C39 O8 C40 C41 155.39(15) . . . . ? C39 O8 C40 C47 -82.59(19) . . . . ? C39 C51 C52 C53 -177.5(2) . . . . ? C39 C51 C56 C55 176.6(2) . . . . ? C40 O8 C39 C38 -22.1(2) . . . . ? C40 O8 C39 C49 99.1(2) . . . . ? C40 O8 C39 C51 -146.42(16) . . . . ? C40 C36 C37 N2 -114.18(19) . . . . ? C40 C36 C38 C39 16.6(2) . . . . ? C40 C41 C42 C43 179.0(2) . . . . ? C40 C41 C46 C45 -179.5(2) . . . . ? C41 C40 C47 O9 -153.1(2) . . . . ? C41 C40 C47 O10 29.9(3) . . . . ? C41 C42 C43 C44 1.7(4) . . . . ? C42 C41 C46 C45 1.4(4) . . . . ? C42 C43 C44 C45 -0.9(5) . . . . ? C43 C44 C45 C46 0.4(5) . . . . ? C44 C45 C46 C41 -0.6(4) . . . . ? C46 C41 C42 C43 -1.9(4) . . . . ? C47 C40 C41 C42 -124.8(2) . . . . ? C47 C40 C41 C46 56.0(3) . . . . ? C48 O10 C47 O9 -0.6(4) . . . . ? C48 O10 C47 C40 176.5(2) . . . . ? C49 C39 C51 C52 100.4(2) . . . . ? C49 C39 C51 C56 -76.3(2) . . . . ? C50 O12 C49 O11 -0.4(4) . . . . ? C50 O12 C49 C39 175.4(2) . . . . ? C51 C39 C49 O11 89.6(3) . . . . ? C51 C39 C49 O12 -86.2(2) . . . . ? C51 C52 C53 C54 1.3(4) . . . . ? C52 C51 C56 C55 -0.1(4) . . . . ? C52 C53 C54 C55 -0.8(4) . . . . ? C53 C54 C55 C56 0.0(4) . . . . ? C54 C55 C56 C51 0.5(4) . . . . ? C56 C51 C52 C53 -0.8(4) . . . . ?