#------------------------------------------------------------------------------ #$Date: 2020-10-06 14:17:07 +0300 (Tue, 06 Oct 2020) $ #$Revision: 257989 $ #$URL: file:///home/coder/svn-repositories/cod/cif/7/24/04/7240402.cif $ #------------------------------------------------------------------------------ # # This file is available in the Crystallography Open Database (COD), # http://www.crystallography.net/ # # All data on this site have been placed in the public domain by the # contributors. # data_7240402 loop_ _publ_author_name 'Bhandari, Sonal' 'Sana, Sravani' 'Lahoti, Vandana' 'Tokala, Ramya' 'Shankaraiah, Nagula' _publ_section_title ; Ring-opening cyclization of activated spiro-aziridine oxindoles with heteroarenes: a facile synthetic approach to spiro-oxindole-fused pyrroloindolines ; _journal_issue 27 _journal_name_full 'RSC Advances' _journal_page_first 16101 _journal_page_last 16109 _journal_paper_doi 10.1039/D0RA00684J _journal_volume 10 _journal_year 2020 _chemical_absolute_configuration rmad _chemical_formula_moiety 'C24 H28 Cl N3 O3 S' _chemical_formula_sum 'C24 H28 Cl N3 O3 S' _chemical_formula_weight 474.00 _space_group_crystal_system tetragonal _space_group_IT_number 78 _space_group_name_Hall 'P 4cw' _space_group_name_H-M_alt 'P 43' _atom_sites_solution_hydrogens geom _audit_creation_method SHELXL-2018/3 _audit_update_record ; 2019-12-06 deposited with the CCDC. 2020-03-31 downloaded from the CCDC. ; _cell_angle_alpha 90 _cell_angle_beta 90 _cell_angle_gamma 90 _cell_formula_units_Z 4 _cell_length_a 7.53409(9) _cell_length_b 7.53409(9) _cell_length_c 42.4001(5) _cell_measurement_reflns_used 8968 _cell_measurement_temperature 294(2) _cell_measurement_theta_max 2.87 _cell_measurement_theta_min 2.70 _cell_volume 2406.74(5) _computing_cell_refinement 'SAINT (Bruker, 2016)' _computing_data_collection 'APEX3 (Bruker, 2016)' _computing_data_reduction 'Bruker SAINT' _computing_molecular_graphics 'Bruker SHELXTL' _computing_publication_material 'Bruker SHELXTL' _computing_structure_refinement 'SHELXL2014 (Sheldrick, 2015)' _computing_structure_solution 'SHELXT (Sheldrick, 2015)' _diffrn_ambient_temperature 294(2) _diffrn_measured_fraction_theta_full 0.999 _diffrn_measured_fraction_theta_max 0.997 _diffrn_measurement_device_type 'Bruker SMART APEX CCD area-detector' _diffrn_measurement_method \w _diffrn_radiation_type MoK\a _diffrn_radiation_wavelength 0.71073 _diffrn_reflns_av_unetI/netI 0.1111 _diffrn_reflns_Laue_measured_fraction_full 0.999 _diffrn_reflns_Laue_measured_fraction_max 0.997 _diffrn_reflns_limit_h_max 9 _diffrn_reflns_limit_h_min -8 _diffrn_reflns_limit_k_max 9 _diffrn_reflns_limit_k_min -8 _diffrn_reflns_limit_l_max 52 _diffrn_reflns_limit_l_min -52 _diffrn_reflns_number 18924 _diffrn_reflns_point_group_measured_fraction_full 0.997 _diffrn_reflns_point_group_measured_fraction_max 0.990 _diffrn_reflns_theta_full 25.242 _diffrn_reflns_theta_max 26.249 _diffrn_reflns_theta_min 2.704 _exptl_absorpt_coefficient_mu 0.276 _exptl_absorpt_correction_T_max 0.96 _exptl_absorpt_correction_T_min 0.93 _exptl_absorpt_correction_type multi-scan _exptl_absorpt_process_details 'SADABS, Bruker, 2016' _exptl_crystal_colour colorless _exptl_crystal_density_diffrn 1.308 _exptl_crystal_description needle _exptl_crystal_F_000 1000 _exptl_crystal_size_max 0.220 _exptl_crystal_size_mid 0.110 _exptl_crystal_size_min 0.090 _refine_diff_density_max 0.539 _refine_diff_density_min -0.266 _refine_diff_density_rms 0.049 _refine_ls_abs_structure_details ; Flack x determined using 1158 quotients [(I+)-(I-)]/[(I+)+(I-)] (Parsons, Flack and Wagner, Acta Cryst. B69 (2013) 249-259). ; _refine_ls_abs_structure_Flack -0.01(3) _refine_ls_extinction_method none _refine_ls_goodness_of_fit_ref 1.086 _refine_ls_hydrogen_treatment constr _refine_ls_matrix_type full _refine_ls_number_parameters 296 _refine_ls_number_reflns 18924 _refine_ls_number_restraints 1 _refine_ls_restrained_S_all 1.086 _refine_ls_R_factor_all 0.1130 _refine_ls_R_factor_gt 0.0689 _refine_ls_shift/su_max 0.000 _refine_ls_shift/su_mean 0.000 _refine_ls_structure_factor_coef Fsqd _refine_ls_weighting_details 'w=1/[\s^2^(Fo^2^)+1.0826P] where P=(Fo^2^+2Fc^2^)/3' _refine_ls_weighting_scheme calc _refine_ls_wR_factor_gt 0.1226 _refine_ls_wR_factor_ref 0.1363 _reflns_Friedel_coverage 0.959 _reflns_Friedel_fraction_full 0.995 _reflns_Friedel_fraction_max 0.984 _reflns_number_gt 13231 _reflns_number_total 18924 _reflns_threshold_expression 'I > 2\s(I)' _cod_data_source_file d0ra00684j2.cif _cod_data_source_block KA778_TWIN _cod_depositor_comments 'Adding full bibliography for 7240402.cif.' _cod_original_cell_volume 2406.74(6) _cod_database_code 7240402 _shelx_shelxl_version_number 2018/3 _shelx_space_group_comment ; The symmetry employed for this shelxl refinement is uniquely defined by the following loop, which should always be used as a source of symmetry information in preference to the above space-group names. They are only intended as comments. ; _shelx_estimated_absorpt_t_min 0.942 _shelx_estimated_absorpt_t_max 0.976 _shelx_res_file ; TITL KA778_0m_a.res in P4(3) KA778_TWIN.res created by SHELXL-2018/3 at 14:35:51 on 05-Dec-2019 CELL 0.71073 7.53409 7.53409 42.40013 90.000 90.000 90.000 ZERR 4.00 0.00009 0.00009 0.00048 0.000 0.000 0.000 LATT -1 SYMM -y, x, z+3/4 SYMM y, -x, z+1/4 SYMM -x, -y, z+1/2 SFAC C H N O Cl S UNIT 96 112 12 12 4 4 LIST 6 ! automatically inserted. Change 6 to 4 for CHECKCIF!! OMIT -3 52.5 L.S. 10 ACTA BOND $H SIZE 0.22 0.11 0.09 FMAP 2 PLAN 5 CONF TEMP 21.000 WGHT 0.000000 1.082600 BASF 0.09478 FVAR 0.62941 C1 1 0.054931 0.594050 0.469446 11.00000 0.04519 0.03810 = 0.03464 -0.00286 -0.00509 0.00071 AFIX 13 H1 2 -0.003173 0.680125 0.455528 11.00000 -1.20000 AFIX 0 C2 1 -0.139186 0.399056 0.493369 11.00000 0.04558 0.04524 = 0.05109 0.00194 -0.00502 0.00502 C3 1 -0.262311 0.264198 0.498884 11.00000 0.04441 0.04998 = 0.08178 0.00494 -0.00512 0.00899 AFIX 43 H3 2 -0.284031 0.178524 0.483572 11.00000 -1.20000 AFIX 0 C4 1 -0.351566 0.259322 0.527322 11.00000 0.04438 0.08949 = 0.09870 0.03984 0.00504 0.01238 AFIX 43 H4 2 -0.431533 0.168269 0.531496 11.00000 -1.20000 AFIX 0 C5 1 -0.321866 0.389628 0.549488 11.00000 0.04345 0.12493 = 0.06974 0.02533 0.01455 0.02799 AFIX 43 H5 2 -0.384471 0.387436 0.568388 11.00000 -1.20000 AFIX 0 C6 1 -0.200347 0.523592 0.544042 11.00000 0.03489 0.09308 = 0.05243 -0.00132 0.00222 0.01227 AFIX 43 H6 2 -0.180258 0.609622 0.559361 11.00000 -1.20000 AFIX 0 C7 1 -0.108875 0.529677 0.515885 11.00000 0.04722 0.06724 = 0.02548 -0.00268 -0.00235 0.01780 C8 1 0.038729 0.648369 0.504656 11.00000 0.04895 0.03677 = 0.03112 -0.00574 0.00060 0.00651 C9 1 0.226390 0.599331 0.519554 11.00000 0.04946 0.03652 = 0.03031 0.00119 -0.00014 -0.00524 C10 1 0.327895 0.506128 0.492292 11.00000 0.03494 0.05159 = 0.03728 -0.00158 -0.00068 0.00209 AFIX 23 H10A 2 0.454304 0.529782 0.493379 11.00000 -1.20000 H10B 2 0.308391 0.378872 0.492515 11.00000 -1.20000 AFIX 0 C11 1 0.219066 0.490214 0.549625 11.00000 0.03594 0.05956 = 0.02918 -0.00373 -0.00141 0.00982 C12 1 0.150683 0.324937 0.555976 11.00000 0.05507 0.05659 = 0.02825 -0.00553 -0.00393 0.01465 AFIX 43 H12 2 0.103803 0.255118 0.539920 11.00000 -1.20000 AFIX 0 C13 1 0.153177 0.264706 0.586844 11.00000 0.04987 0.06498 = 0.04443 0.01572 0.01110 0.02816 C14 1 0.231910 0.363352 0.610492 11.00000 0.06108 0.09167 = 0.02698 0.01378 0.00825 0.03269 AFIX 43 H14 2 0.238197 0.317128 0.630799 11.00000 -1.20000 AFIX 0 C15 1 0.300599 0.527591 0.604508 11.00000 0.04343 0.08127 = 0.03521 -0.00221 -0.00417 0.01148 AFIX 43 H15 2 0.349429 0.595964 0.620577 11.00000 -1.20000 AFIX 0 C16 1 0.295275 0.588999 0.573830 11.00000 0.02890 0.06305 = 0.03454 -0.00577 0.00040 0.01018 C17 1 0.332810 0.762079 0.530202 11.00000 0.06091 0.04767 = 0.04071 -0.00401 -0.00179 -0.01537 C18 1 0.455249 0.789890 0.424158 11.00000 0.06821 0.05383 = 0.06427 0.00000 0.00833 -0.00803 C19 1 0.330251 0.944220 0.428489 11.00000 0.12693 0.05935 = 0.10248 0.01270 0.01460 -0.00075 AFIX 137 H19A 2 0.391634 1.052991 0.424004 11.00000 -1.50000 H19B 2 0.288097 0.946154 0.449853 11.00000 -1.50000 H19C 2 0.231423 0.931796 0.414369 11.00000 -1.50000 AFIX 0 C20 1 0.608759 0.800781 0.447443 11.00000 0.07272 0.10732 = 0.10327 -0.01163 0.00477 -0.02781 AFIX 137 H20A 2 0.677391 0.905515 0.443252 11.00000 -1.50000 H20B 2 0.682733 0.697798 0.445207 11.00000 -1.50000 H20C 2 0.562923 0.805895 0.468550 11.00000 -1.50000 AFIX 0 C21 1 0.527972 0.783718 0.390162 11.00000 0.16225 0.10852 = 0.06618 0.00164 0.04174 -0.05871 AFIX 137 H21A 2 0.432245 0.800576 0.375522 11.00000 -1.50000 H21B 2 0.582671 0.670571 0.386428 11.00000 -1.50000 H21C 2 0.614254 0.876167 0.387383 11.00000 -1.50000 AFIX 0 C22 1 -0.069554 0.336730 0.437934 11.00000 0.07314 0.08602 = 0.07831 -0.04263 0.00176 -0.01860 AFIX 137 H22A 2 -0.065482 0.210111 0.440365 11.00000 -1.50000 H22B 2 0.016192 0.372822 0.422462 11.00000 -1.50000 H22C 2 -0.186037 0.371610 0.431164 11.00000 -1.50000 AFIX 0 C23 1 -0.012980 0.844100 0.508662 11.00000 0.07897 0.04770 = 0.06190 -0.01111 -0.01220 0.01731 AFIX 137 H23A 2 -0.128133 0.863744 0.499619 11.00000 -1.50000 H23B 2 0.072657 0.917724 0.498177 11.00000 -1.50000 H23C 2 -0.015810 0.873271 0.530697 11.00000 -1.50000 AFIX 0 C24 1 0.475756 0.873659 0.579380 11.00000 0.06781 0.07660 = 0.05374 -0.02383 -0.01272 -0.01149 AFIX 137 H24A 2 0.506598 0.824417 0.599531 11.00000 -1.50000 H24B 2 0.412113 0.982739 0.582392 11.00000 -1.50000 H24C 2 0.581901 0.896346 0.567521 11.00000 -1.50000 AFIX 0 N1 3 -0.029441 0.420442 0.467734 11.00000 0.06062 0.06113 = 0.04507 -0.02175 0.00610 -0.01016 N2 3 0.247418 0.589010 0.464313 11.00000 0.04522 0.06068 = 0.02321 0.00506 -0.00639 -0.00346 N3 3 0.363554 0.747417 0.562089 11.00000 0.05332 0.05987 = 0.03753 -0.01402 -0.00594 -0.01427 O1 4 0.469040 0.442869 0.429444 11.00000 0.08388 0.05428 = 0.05786 -0.00787 0.02101 0.00974 O2 4 0.200688 0.582726 0.406949 11.00000 0.09275 0.11893 = 0.02409 0.00298 -0.00874 -0.02505 O3 4 0.386488 0.884087 0.514235 11.00000 0.10354 0.05815 = 0.05119 -0.00054 -0.00835 -0.02514 CL1 5 0.055094 0.062650 0.595955 11.00000 0.09420 0.07294 = 0.07595 0.02359 0.01603 0.00947 S1 6 0.340566 0.583920 0.429653 11.00000 0.05955 0.05923 = 0.02859 -0.00226 0.00363 -0.00917 HKLF 5 REM KA778_0m_a.res in P4(3) REM wR2 = 0.1363, GooF = S = 1.086, Restrained GooF = 1.086 for all data REM R1 = 0.0689 for 13231 Fo > 4sig(Fo) and 0.1130 for all 18924 data REM 296 parameters refined using 1 restraints END WGHT 0.0000 1.0826 REM Highest difference peak 0.539, deepest hole -0.266, 1-sigma level 0.049 Q1 1 0.3378 0.5926 0.4532 11.00000 0.05 0.29 Q2 1 0.3449 0.5837 0.4052 11.00000 0.05 0.29 Q3 1 -0.0941 0.4499 0.4273 11.00000 0.05 0.23 Q4 1 0.2413 0.5196 0.4698 11.00000 0.05 0.22 Q5 1 0.3994 0.8317 0.4874 11.00000 0.05 0.20 ; _shelx_res_checksum 29726 loop_ _space_group_symop_operation_xyz 'x, y, z' '-y, x, z+3/4' 'y, -x, z+1/4' '-x, -y, z+1/2' loop_ _atom_site_label _atom_site_type_symbol _atom_site_fract_x _atom_site_fract_y _atom_site_fract_z _atom_site_U_iso_or_equiv _atom_site_adp_type _atom_site_occupancy _atom_site_site_symmetry_order _atom_site_calc_flag _atom_site_refinement_flags_posn _atom_site_refinement_flags_adp _atom_site_refinement_flags_occupancy _atom_site_disorder_assembly _atom_site_disorder_group C1 C 0.0549(11) 0.5941(11) 0.46945(16) 0.039(2) Uani 1 1 d . . . . . H1 H -0.003173 0.680125 0.455528 0.047 Uiso 1 1 calc R U . . . C2 C -0.1392(12) 0.3991(12) 0.49337(18) 0.047(2) Uani 1 1 d . . . . . C3 C -0.2623(13) 0.2642(13) 0.4989(2) 0.059(2) Uani 1 1 d . . . . . H3 H -0.284031 0.178524 0.483572 0.070 Uiso 1 1 calc R U . . . C4 C -0.3516(14) 0.2593(17) 0.5273(3) 0.078(3) Uani 1 1 d . . . . . H4 H -0.431533 0.168269 0.531496 0.093 Uiso 1 1 calc R U . . . C5 C -0.3219(15) 0.3896(19) 0.5495(2) 0.079(3) Uani 1 1 d . . . . . H5 H -0.384471 0.387436 0.568388 0.095 Uiso 1 1 calc R U . . . C6 C -0.2003(12) 0.5236(16) 0.54404(19) 0.060(3) Uani 1 1 d . . . . . H6 H -0.180258 0.609622 0.559361 0.072 Uiso 1 1 calc R U . . . C7 C -0.1089(12) 0.5297(12) 0.51588(16) 0.047(2) Uani 1 1 d . . . . . C8 C 0.0387(11) 0.6484(11) 0.50466(15) 0.039(2) Uani 1 1 d . . . . . C9 C 0.2264(11) 0.5993(10) 0.51955(15) 0.039(2) Uani 1 1 d . . . . . C10 C 0.3279(10) 0.5061(11) 0.49229(14) 0.041(2) Uani 1 1 d . . . . . H10A H 0.454304 0.529782 0.493379 0.050 Uiso 1 1 calc R U . . . H10B H 0.308391 0.378872 0.492515 0.050 Uiso 1 1 calc R U . . . C11 C 0.2191(11) 0.4902(13) 0.54962(16) 0.042(2) Uani 1 1 d . . . . . C12 C 0.1507(12) 0.3249(13) 0.55598(16) 0.047(2) Uani 1 1 d . . . . . H12 H 0.103803 0.255118 0.539920 0.056 Uiso 1 1 calc R U . . . C13 C 0.1532(12) 0.2647(13) 0.58684(18) 0.053(3) Uani 1 1 d . . . . . C14 C 0.2319(13) 0.3634(16) 0.61049(19) 0.060(3) Uani 1 1 d . . . . . H14 H 0.238197 0.317128 0.630799 0.072 Uiso 1 1 calc R U . . . C15 C 0.3006(11) 0.5276(15) 0.60451(17) 0.053(3) Uani 1 1 d . . . . . H15 H 0.349429 0.595964 0.620577 0.064 Uiso 1 1 calc R U . . . C16 C 0.2953(11) 0.5890(13) 0.57383(16) 0.042(2) Uani 1 1 d . . . . . C17 C 0.3328(12) 0.7621(13) 0.53020(18) 0.050(2) Uani 1 1 d . . . . . C18 C 0.4552(14) 0.7899(13) 0.4242(2) 0.062(3) Uani 1 1 d . . . . . C19 C 0.3303(18) 0.9442(15) 0.4285(3) 0.096(4) Uani 1 1 d . . . . . H19A H 0.391634 1.052991 0.424004 0.144 Uiso 1 1 calc R U . . . H19B H 0.288097 0.946154 0.449853 0.144 Uiso 1 1 calc R U . . . H19C H 0.231423 0.931796 0.414369 0.144 Uiso 1 1 calc R U . . . C20 C 0.6088(16) 0.8008(18) 0.4474(2) 0.094(4) Uani 1 1 d . . . . . H20A H 0.677391 0.905515 0.443252 0.142 Uiso 1 1 calc R U . . . H20B H 0.682733 0.697798 0.445207 0.142 Uiso 1 1 calc R U . . . H20C H 0.562923 0.805895 0.468550 0.142 Uiso 1 1 calc R U . . . C21 C 0.528(2) 0.7837(17) 0.3902(2) 0.112(5) Uani 1 1 d . . . . . H21A H 0.432245 0.800576 0.375522 0.168 Uiso 1 1 calc R U . . . H21B H 0.582671 0.670571 0.386428 0.168 Uiso 1 1 calc R U . . . H21C H 0.614254 0.876167 0.387383 0.168 Uiso 1 1 calc R U . . . C22 C -0.0696(14) 0.3367(15) 0.4379(2) 0.079(3) Uani 1 1 d . . . . . H22A H -0.065482 0.210111 0.440365 0.119 Uiso 1 1 calc R U . . . H22B H 0.016192 0.372822 0.422462 0.119 Uiso 1 1 calc R U . . . H22C H -0.186037 0.371610 0.431164 0.119 Uiso 1 1 calc R U . . . C23 C -0.0130(14) 0.8441(12) 0.50866(19) 0.063(3) Uani 1 1 d . . . . . H23A H -0.128133 0.863744 0.499619 0.094 Uiso 1 1 calc R U . . . H23B H 0.072657 0.917724 0.498177 0.094 Uiso 1 1 calc R U . . . H23C H -0.015810 0.873271 0.530697 0.094 Uiso 1 1 calc R U . . . C24 C 0.4758(13) 0.8737(14) 0.57938(19) 0.066(3) Uani 1 1 d . . . . . H24A H 0.506598 0.824417 0.599531 0.099 Uiso 1 1 calc R U . . . H24B H 0.412113 0.982739 0.582392 0.099 Uiso 1 1 calc R U . . . H24C H 0.581901 0.896346 0.567521 0.099 Uiso 1 1 calc R U . . . N1 N -0.0294(10) 0.4204(10) 0.46773(15) 0.056(2) Uani 1 1 d . . . . . N2 N 0.2474(9) 0.5890(9) 0.46431(12) 0.0430(18) Uani 1 1 d . . . . . N3 N 0.3636(9) 0.7474(11) 0.56209(13) 0.050(2) Uani 1 1 d . . . . . O1 O 0.4690(9) 0.4429(8) 0.42944(13) 0.0653(17) Uani 1 1 d . . . . . O2 O 0.2007(9) 0.5827(10) 0.40695(10) 0.079(2) Uani 1 1 d . . . . . O3 O 0.3865(10) 0.8841(9) 0.51424(12) 0.071(2) Uani 1 1 d . . . . . Cl1 Cl 0.0551(4) 0.0627(4) 0.59596(6) 0.0810(9) Uani 1 1 d . . . . . S1 S 0.3406(3) 0.5839(3) 0.42965(4) 0.0491(6) Uani 1 1 d . . . . . loop_ _atom_site_aniso_label _atom_site_aniso_U_11 _atom_site_aniso_U_22 _atom_site_aniso_U_33 _atom_site_aniso_U_23 _atom_site_aniso_U_13 _atom_site_aniso_U_12 C1 0.045(6) 0.038(5) 0.035(4) -0.003(4) -0.005(4) 0.001(5) C2 0.046(6) 0.045(6) 0.051(5) 0.002(4) -0.005(4) 0.005(5) C3 0.044(6) 0.050(6) 0.082(6) 0.005(5) -0.005(5) 0.009(5) C4 0.044(7) 0.089(10) 0.099(8) 0.040(7) 0.005(6) 0.012(6) C5 0.043(7) 0.125(11) 0.070(7) 0.025(7) 0.015(5) 0.028(8) C6 0.035(6) 0.093(8) 0.052(5) -0.001(5) 0.002(4) 0.012(6) C7 0.047(6) 0.067(7) 0.025(4) -0.003(4) -0.002(4) 0.018(5) C8 0.049(6) 0.037(5) 0.031(4) -0.006(3) 0.001(4) 0.007(5) C9 0.049(6) 0.037(5) 0.030(4) 0.001(3) 0.000(4) -0.005(4) C10 0.035(5) 0.052(6) 0.037(4) -0.002(4) -0.001(4) 0.002(4) C11 0.036(5) 0.060(6) 0.029(4) -0.004(4) -0.001(3) 0.010(5) C12 0.055(6) 0.057(7) 0.028(4) -0.006(4) -0.004(4) 0.015(5) C13 0.050(6) 0.065(7) 0.044(5) 0.016(5) 0.011(4) 0.028(5) C14 0.061(7) 0.092(9) 0.027(4) 0.014(5) 0.008(4) 0.033(6) C15 0.043(6) 0.081(8) 0.035(4) -0.002(5) -0.004(4) 0.011(6) C16 0.029(5) 0.063(6) 0.035(4) -0.006(4) 0.000(3) 0.010(5) C17 0.061(7) 0.048(6) 0.041(5) -0.004(4) -0.002(4) -0.015(5) C18 0.068(7) 0.054(7) 0.064(6) 0.000(5) 0.008(5) -0.008(6) C19 0.127(11) 0.059(8) 0.102(8) 0.013(6) 0.015(8) -0.001(8) C20 0.073(9) 0.107(10) 0.103(8) -0.012(7) 0.005(7) -0.028(8) C21 0.162(14) 0.109(10) 0.066(6) 0.002(6) 0.042(7) -0.059(9) C22 0.073(8) 0.086(8) 0.078(6) -0.043(6) 0.002(6) -0.019(6) C23 0.079(8) 0.048(7) 0.062(5) -0.011(4) -0.012(5) 0.017(6) C24 0.068(7) 0.077(8) 0.054(5) -0.024(5) -0.013(5) -0.011(6) N1 0.061(5) 0.061(5) 0.045(4) -0.022(4) 0.006(4) -0.010(5) N2 0.045(5) 0.061(5) 0.023(3) 0.005(3) -0.006(3) -0.003(4) N3 0.053(5) 0.060(6) 0.038(4) -0.014(4) -0.006(3) -0.014(4) O1 0.084(5) 0.054(4) 0.058(3) -0.008(3) 0.021(3) 0.010(4) O2 0.093(5) 0.119(6) 0.024(3) 0.003(3) -0.009(3) -0.025(5) O3 0.104(6) 0.058(5) 0.051(3) -0.001(3) -0.008(3) -0.025(4) Cl1 0.094(2) 0.073(2) 0.0760(15) 0.0236(14) 0.0160(15) 0.0095(17) S1 0.0595(17) 0.0592(17) 0.0286(9) -0.0023(10) 0.0036(10) -0.0092(14) loop_ _atom_type_symbol _atom_type_description _atom_type_scat_dispersion_real _atom_type_scat_dispersion_imag _atom_type_scat_source C C 0.0033 0.0016 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' N N 0.0061 0.0033 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' O O 0.0106 0.0060 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' Cl Cl 0.1484 0.1585 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' S S 0.1246 0.1234 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' loop_ _geom_angle_atom_site_label_1 _geom_angle_atom_site_label_2 _geom_angle_atom_site_label_3 _geom_angle _geom_angle_site_symmetry_1 _geom_angle_site_symmetry_3 _geom_angle_publ_flag N1 C1 N2 113.6(7) . . ? N1 C1 C8 104.5(6) . . ? N2 C1 C8 103.1(6) . . ? N1 C1 H1 111.7 . . ? N2 C1 H1 111.7 . . ? C8 C1 H1 111.7 . . ? N1 C2 C7 111.2(8) . . ? N1 C2 C3 128.1(8) . . ? C7 C2 C3 120.6(8) . . ? C4 C3 C2 119.3(9) . . ? C4 C3 H3 120.4 . . ? C2 C3 H3 120.4 . . ? C5 C4 C3 119.8(11) . . ? C5 C4 H4 120.1 . . ? C3 C4 H4 120.1 . . ? C4 C5 C6 120.9(9) . . ? C4 C5 H5 119.5 . . ? C6 C5 H5 119.5 . . ? C7 C6 C5 120.0(10) . . ? C7 C6 H6 120.0 . . ? C5 C6 H6 120.0 . . ? C6 C7 C2 119.3(9) . . ? C6 C7 C8 131.5(8) . . ? C2 C7 C8 109.0(6) . . ? C7 C8 C23 110.4(7) . . ? C7 C8 C1 101.9(6) . . ? C23 C8 C1 112.3(6) . . ? C7 C8 C9 113.1(6) . . ? C23 C8 C9 113.9(7) . . ? C1 C8 C9 104.5(6) . . ? C11 C9 C17 101.8(6) . . ? C11 C9 C10 113.5(7) . . ? C17 C9 C10 108.9(7) . . ? C11 C9 C8 115.3(6) . . ? C17 C9 C8 113.3(7) . . ? C10 C9 C8 104.3(5) . . ? N2 C10 C9 101.8(6) . . ? N2 C10 H10A 111.4 . . ? C9 C10 H10A 111.4 . . ? N2 C10 H10B 111.4 . . ? C9 C10 H10B 111.4 . . ? H10A C10 H10B 109.3 . . ? C12 C11 C16 119.7(7) . . ? C12 C11 C9 132.0(7) . . ? C16 C11 C9 108.3(8) . . ? C11 C12 C13 118.5(8) . . ? C11 C12 H12 120.8 . . ? C13 C12 H12 120.8 . . ? C14 C13 C12 121.0(9) . . ? C14 C13 Cl1 119.5(7) . . ? C12 C13 Cl1 119.5(8) . . ? C15 C14 C13 121.0(8) . . ? C15 C14 H14 119.5 . . ? C13 C14 H14 119.5 . . ? C14 C15 C16 117.9(8) . . ? C14 C15 H15 121.1 . . ? C16 C15 H15 121.1 . . ? C15 C16 C11 121.8(9) . . ? C15 C16 N3 127.8(8) . . ? C11 C16 N3 110.3(7) . . ? O3 C17 N3 123.6(8) . . ? O3 C17 C9 128.1(7) . . ? N3 C17 C9 108.3(7) . . ? C19 C18 C20 110.7(9) . . ? C19 C18 C21 111.0(9) . . ? C20 C18 C21 109.7(10) . . ? C19 C18 S1 110.5(7) . . ? C20 C18 S1 109.2(7) . . ? C21 C18 S1 105.5(7) . . ? C18 C19 H19A 109.5 . . ? C18 C19 H19B 109.5 . . ? H19A C19 H19B 109.5 . . ? C18 C19 H19C 109.5 . . ? H19A C19 H19C 109.5 . . ? H19B C19 H19C 109.5 . . ? C18 C20 H20A 109.5 . . ? C18 C20 H20B 109.5 . . ? H20A C20 H20B 109.5 . . ? C18 C20 H20C 109.5 . . ? H20A C20 H20C 109.5 . . ? H20B C20 H20C 109.5 . . ? C18 C21 H21A 109.5 . . ? C18 C21 H21B 109.5 . . ? H21A C21 H21B 109.5 . . ? C18 C21 H21C 109.5 . . ? H21A C21 H21C 109.5 . . ? H21B C21 H21C 109.5 . . ? N1 C22 H22A 109.5 . . ? N1 C22 H22B 109.5 . . ? H22A C22 H22B 109.5 . . ? N1 C22 H22C 109.5 . . ? H22A C22 H22C 109.5 . . ? H22B C22 H22C 109.5 . . ? C8 C23 H23A 109.5 . . ? C8 C23 H23B 109.5 . . ? H23A C23 H23B 109.5 . . ? C8 C23 H23C 109.5 . . ? H23A C23 H23C 109.5 . . ? H23B C23 H23C 109.5 . . ? N3 C24 H24A 109.5 . . ? N3 C24 H24B 109.5 . . ? H24A C24 H24B 109.5 . . ? N3 C24 H24C 109.5 . . ? H24A C24 H24C 109.5 . . ? H24B C24 H24C 109.5 . . ? C2 N1 C22 121.0(8) . . ? C2 N1 C1 109.2(6) . . ? C22 N1 C1 121.8(7) . . ? C1 N2 C10 107.4(6) . . ? C1 N2 S1 124.1(5) . . ? C10 N2 S1 122.7(5) . . ? C17 N3 C16 111.0(6) . . ? C17 N3 C24 122.4(7) . . ? C16 N3 C24 126.1(6) . . ? O2 S1 O1 119.2(4) . . ? O2 S1 N2 106.9(4) . . ? O1 S1 N2 108.2(3) . . ? O2 S1 C18 105.9(4) . . ? O1 S1 C18 108.4(4) . . ? N2 S1 C18 107.7(4) . . ? loop_ _geom_bond_atom_site_label_1 _geom_bond_atom_site_label_2 _geom_bond_distance _geom_bond_site_symmetry_2 _geom_bond_publ_flag C1 N1 1.456(10) . ? C1 N2 1.467(10) . ? C1 C8 1.553(9) . ? C1 H1 0.9800 . ? C2 N1 1.375(10) . ? C2 C7 1.390(11) . ? C2 C3 1.396(13) . ? C3 C4 1.381(13) . ? C3 H3 0.9300 . ? C4 C5 1.377(16) . ? C4 H4 0.9300 . ? C5 C6 1.382(16) . ? C5 H5 0.9300 . ? C6 C7 1.379(11) . ? C6 H6 0.9300 . ? C7 C8 1.504(12) . ? C8 C23 1.535(12) . ? C8 C9 1.592(11) . ? C9 C11 1.518(11) . ? C9 C17 1.533(12) . ? C9 C10 1.554(10) . ? C10 N2 1.471(9) . ? C10 H10A 0.9700 . ? C10 H10B 0.9700 . ? C11 C12 1.374(12) . ? C11 C16 1.392(11) . ? C12 C13 1.385(10) . ? C12 H12 0.9300 . ? C13 C14 1.382(13) . ? C13 Cl1 1.736(10) . ? C14 C15 1.365(14) . ? C14 H14 0.9300 . ? C15 C16 1.381(11) . ? C15 H15 0.9300 . ? C16 N3 1.392(11) . ? C17 O3 1.211(9) . ? C17 N3 1.376(10) . ? C18 C19 1.508(14) . ? C18 C20 1.523(14) . ? C18 C21 1.543(12) . ? C18 S1 1.791(10) . ? C19 H19A 0.9600 . ? C19 H19B 0.9600 . ? C19 H19C 0.9600 . ? C20 H20A 0.9600 . ? C20 H20B 0.9600 . ? C20 H20C 0.9600 . ? C21 H21A 0.9600 . ? C21 H21B 0.9600 . ? C21 H21C 0.9600 . ? C22 N1 1.444(10) . ? C22 H22A 0.9600 . ? C22 H22B 0.9600 . ? C22 H22C 0.9600 . ? C23 H23A 0.9600 . ? C23 H23B 0.9600 . ? C23 H23C 0.9600 . ? C24 N3 1.469(11) . ? C24 H24A 0.9600 . ? C24 H24B 0.9600 . ? C24 H24C 0.9600 . ? N2 S1 1.629(6) . ? O1 S1 1.437(6) . ? O2 S1 1.427(6) . ? loop_ _geom_torsion_atom_site_label_1 _geom_torsion_atom_site_label_2 _geom_torsion_atom_site_label_3 _geom_torsion_atom_site_label_4 _geom_torsion _geom_torsion_site_symmetry_1 _geom_torsion_site_symmetry_2 _geom_torsion_site_symmetry_3 _geom_torsion_site_symmetry_4 _geom_torsion_publ_flag N1 C2 C3 C4 175.4(8) . . . . ? C7 C2 C3 C4 -1.4(12) . . . . ? C2 C3 C4 C5 1.8(14) . . . . ? C3 C4 C5 C6 -1.6(15) . . . . ? C4 C5 C6 C7 1.0(14) . . . . ? C5 C6 C7 C2 -0.6(13) . . . . ? C5 C6 C7 C8 -174.4(8) . . . . ? N1 C2 C7 C6 -176.5(8) . . . . ? C3 C2 C7 C6 0.8(12) . . . . ? N1 C2 C7 C8 -1.4(9) . . . . ? C3 C2 C7 C8 175.9(7) . . . . ? C6 C7 C8 C23 -53.0(11) . . . . ? C2 C7 C8 C23 132.7(7) . . . . ? C6 C7 C8 C1 -172.5(9) . . . . ? C2 C7 C8 C1 13.2(8) . . . . ? C6 C7 C8 C9 75.9(11) . . . . ? C2 C7 C8 C9 -98.4(7) . . . . ? N1 C1 C8 C7 -19.6(7) . . . . ? N2 C1 C8 C7 -138.7(6) . . . . ? N1 C1 C8 C23 -137.7(8) . . . . ? N2 C1 C8 C23 103.2(8) . . . . ? N1 C1 C8 C9 98.4(7) . . . . ? N2 C1 C8 C9 -20.7(8) . . . . ? C7 C8 C9 C11 -19.8(9) . . . . ? C23 C8 C9 C11 107.3(8) . . . . ? C1 C8 C9 C11 -129.8(7) . . . . ? C7 C8 C9 C17 -136.6(6) . . . . ? C23 C8 C9 C17 -9.5(9) . . . . ? C1 C8 C9 C17 113.4(7) . . . . ? C7 C8 C9 C10 105.2(6) . . . . ? C23 C8 C9 C10 -127.7(7) . . . . ? C1 C8 C9 C10 -4.8(8) . . . . ? C11 C9 C10 N2 154.5(7) . . . . ? C17 C9 C10 N2 -92.9(7) . . . . ? C8 C9 C10 N2 28.3(7) . . . . ? C17 C9 C11 C12 -176.4(9) . . . . ? C10 C9 C11 C12 -59.6(12) . . . . ? C8 C9 C11 C12 60.6(12) . . . . ? C17 C9 C11 C16 5.3(9) . . . . ? C10 C9 C11 C16 122.0(7) . . . . ? C8 C9 C11 C16 -117.8(7) . . . . ? C16 C11 C12 C13 2.7(12) . . . . ? C9 C11 C12 C13 -175.5(8) . . . . ? C11 C12 C13 C14 -3.8(12) . . . . ? C11 C12 C13 Cl1 175.9(7) . . . . ? C12 C13 C14 C15 3.8(13) . . . . ? Cl1 C13 C14 C15 -176.0(7) . . . . ? C13 C14 C15 C16 -2.5(13) . . . . ? C14 C15 C16 C11 1.5(12) . . . . ? C14 C15 C16 N3 -177.0(8) . . . . ? C12 C11 C16 C15 -1.6(12) . . . . ? C9 C11 C16 C15 177.0(7) . . . . ? C12 C11 C16 N3 177.1(8) . . . . ? C9 C11 C16 N3 -4.3(9) . . . . ? C11 C9 C17 O3 174.2(10) . . . . ? C10 C9 C17 O3 54.1(12) . . . . ? C8 C9 C17 O3 -61.4(12) . . . . ? C11 C9 C17 N3 -4.5(9) . . . . ? C10 C9 C17 N3 -124.6(7) . . . . ? C8 C9 C17 N3 119.8(7) . . . . ? C7 C2 N1 C22 -161.6(8) . . . . ? C3 C2 N1 C22 21.4(14) . . . . ? C7 C2 N1 C1 -12.3(9) . . . . ? C3 C2 N1 C1 170.6(8) . . . . ? N2 C1 N1 C2 131.8(7) . . . . ? C8 C1 N1 C2 20.1(8) . . . . ? N2 C1 N1 C22 -79.2(9) . . . . ? C8 C1 N1 C22 169.1(8) . . . . ? N1 C1 N2 C10 -71.3(7) . . . . ? C8 C1 N2 C10 41.2(7) . . . . ? N1 C1 N2 S1 82.2(8) . . . . ? C8 C1 N2 S1 -165.3(5) . . . . ? C9 C10 N2 C1 -44.2(7) . . . . ? C9 C10 N2 S1 161.9(5) . . . . ? O3 C17 N3 C16 -176.5(10) . . . . ? C9 C17 N3 C16 2.3(9) . . . . ? O3 C17 N3 C24 -4.3(14) . . . . ? C9 C17 N3 C24 174.5(8) . . . . ? C15 C16 N3 C17 179.9(8) . . . . ? C11 C16 N3 C17 1.2(9) . . . . ? C15 C16 N3 C24 8.1(14) . . . . ? C11 C16 N3 C24 -170.6(8) . . . . ? C1 N2 S1 O2 -0.8(8) . . . . ? C10 N2 S1 O2 148.7(6) . . . . ? C1 N2 S1 O1 -130.4(7) . . . . ? C10 N2 S1 O1 19.1(7) . . . . ? C1 N2 S1 C18 112.6(7) . . . . ? C10 N2 S1 C18 -97.8(7) . . . . ? C19 C18 S1 O2 58.5(8) . . . . ? C20 C18 S1 O2 -179.4(7) . . . . ? C21 C18 S1 O2 -61.6(8) . . . . ? C19 C18 S1 O1 -172.5(7) . . . . ? C20 C18 S1 O1 -50.4(8) . . . . ? C21 C18 S1 O1 67.4(8) . . . . ? C19 C18 S1 N2 -55.6(8) . . . . ? C20 C18 S1 N2 66.5(8) . . . . ? C21 C18 S1 N2 -175.7(8) . . . . ?